Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs

Circulation
J D RutherfordE Braunwald

Abstract

The effects of aminophylline, 1 mg/kg/min infused intravenously for 10 minutes, were examined on left ventricular (LV) diameter, pressure, an indexes of myocardial contractility, as well as systemic, coronary and regional hemodynamics in conscious dogs. Aminophylline increased mean arterial pressure 12 +/- 2%, LV systolic pressure 8 +/- 1%, LV dP/dt 20 +/- 2%, velocity of myocardial fiber shortening 13 +/- 2% and heart rate 5 +/- 2%, and reduced LV end-diastolic diameter 2 +/- 0.5%. Vascular resistance rose in the systemic bed 13 +/- 5%, the coronary bed 26 +/- 3%, the mesenteric bed 26 +/- 5% and the iliac bed 36 +/- 4%, but did not rise in the renal bed. Both beta-adrenergic receptor blockade with propranolol and chronic treatment with reserpine attentuated but did not abolish the positive inotropic response induced by aminophylline. Alpha-adrenergic receptor blockade with phentolamine prevented aminophylline-induced vasoconstriction in the systemic, coronary, mesenteric and iliac beds. In contrast to the vasoconstriction with i.v. aminophylline, when the drug was infused directly into the iliac artery, it elicited marked iliac vasodilation. Thus, in the intact conscious dog, i.v. aminophylline, in a dose that had little effe...Continue Reading

References

Feb 1, 1977·Canadian Journal of Physiology and Pharmacology·T T Martinez, J H McNeil
Nov 6, 1975·The New England Journal of Medicine·S F Vatner, E Braunwald
Jun 1, 1972·The American Journal of Physiology·M L MarcusS E Epstein
Jun 1, 1972·British Journal of Pharmacology·R Massingham, P A Nasmyth
Oct 1, 1974·British Journal of Pharmacology·P Bellemann, H Scholz
Aug 1, 1974·Journal of Applied Physiology·T A PatrickD Franklin
Dec 1, 1970·Journal of Applied Physiology·S F VatnerR L VanCitters
Feb 1, 1966·The American Journal of Cardiology·J O ParkerR O West
Feb 1, 1949·Archives of Internal Medicine·D M FOWELL, J A WINSLOW

❮ Previous
Next ❯

Citations

Jan 1, 1986·International Journal of Cardiac Imaging·B Shively, N B Schiller
Aug 1, 1988·The Journal of Allergy and Clinical Immunology·T IshizakiM Yamaguchi
Apr 1, 1993·Journal of the American College of Cardiology·G V HellerC E Garber
Jun 1, 1995·Journal of the American College of Cardiology·H YoshioR Takeda
Nov 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Harun FakiogluJack Wolfsdorf
Feb 24, 2001·Journal of the American College of Cardiology·P BogatyG R Dagenais
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki MoriiKen Kanamasa
Aug 26, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Soo-Han LeeGyu-Jeong Noh
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Andreas LundinPeter Lundgren
Dec 17, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·David M AxelrodStephen J Roth
Feb 1, 1991·Experimental Eye Research·M J BuschP F Hoyng
Jan 1, 1989·The American Journal of Cardiology·E PicanoA L'Abbate
Aug 1, 1989·American Heart Journal·E PicanoA L'Abbate
Jul 20, 1983·The American Journal of Cardiology·D E Wilcken
Dec 1, 1981·The American Journal of Cardiology·J D RutherfordE Braunwald
Sep 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·J O ErrecaldeM S Mülders
Sep 1, 1988·Pharmacology & Toxicology·J E Nielsen-Kudsk, J Askholt
Nov 1, 1986·The Journal of Pediatrics·F J WaltherP Y Wu
Nov 15, 1989·Journal of the American College of Cardiology·R O Cannon
Jul 1, 1990·Chest·H S Friedman, G Bittar
Jun 1, 1996·Human & Experimental Toxicology·N A Minton, J A Henry
Jan 30, 2020·Journal of Biomolecular Structure & Dynamics·Saniyya KhanImrana Naseem
Jul 14, 2017·Journal of Cardiovascular Pharmacology·Lorenzo ConteAlberto Giannoni
May 1, 1986·Medical Toxicology·P Gaudreault, J Guay
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·A TuranN Süt
Dec 1, 1983·Circulation·T H Hintze, S F Vatner

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