Jun 24, 2020

Effects and pathophysiological significance of intestinal flora on the enteric neuro-endocrine-immune system

Sheng li xue bao : [Acta physiologica Sinica]
Han-Nan XuGuo-Hua Zhang


Interactions among the nervous, the endocrine and the immune systems enable the gut to respond to the dietary products, pathogens and microbiota, which maintains the homeostasis of the body. However, dysbiosis may induce or aggravate the gastrointestinal (GI) and extra-GI diseases through changing the activities of enteric nervous system (ENS), enteroendocrine cells and enteric immune cells. Here we review recent advances in the understandings on how intestinal flora may impact the enteric neuro-endocrine-immune system in the gut, thereby contributing to the regulation of pathophysiological processes.

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Mentioned in this Paper

Immune System
Enteroendocrine Cell
Gastrointestinal Diseases
Immune Effector Cell
Neurosecretory Systems
Nerve Tissue

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