Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer's Disease

Oxidative Medicine and Cellular Longevity
Rongzi LiJeganathan Ramesh Babu

Abstract

Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. Alzheimer's disease is a progressive brain disorder characterized by a chronic loss of cognitive and behavioral function. Considering the shared characteristics of both diseases, common therapeutic and preventive agents may be effective. Bioactive compounds such as polyphenols, vitamins, and carotenoids found in vegetables and fruits can have antioxidant and anti-inflammatory effects. These effects make them suitable candidates for the prevention or treatment of diabetes and Alzheimer's disease. Increasing evidence from cell or animal models suggest that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion, and preventing formation of amyloid plaques. The possible underlying molecular mechanisms are described in this review. More studies are needed to establish the clinical effects of bioactive compounds.

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Citations

Oct 1, 2020·Critical Reviews in Food Science and Nutrition·Davi Vieira Teixeira da SilvaVania Margaret Flosi Paschoalin
Sep 5, 2020·Drug Design, Development and Therapy·Rong-Zi LiJeganathan Ramesh Babu
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Mar 31, 2021·Brain Plasticity·Daniel Joseph Lamport, Claire Michelle Williams
Aug 10, 2021·Frontiers in Physiology·Karoline FelisbinoIzonete Cristina Guiloski

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