Effects in rats of iron on lead deprivation

Biological Trace Element Research
E O Uthus, F H Nielsen

Abstract

In two fully crossed, two-factor experiments, F1 generation male rats were fed a basal diet supplemented with lead (lead acetate) at 0 or 2 micrograms/g and iron (ferric sulfate) at 50 or 250 micrograms/g (Experiment 1). Supplements in Experiment 2 were lead at 0 or 1 micrograms/g and iron at 50, 250, or 1000 micrograms/g. After 28 or 50 d in Experiment 1, and 35 d in Experiment 2, a relationship between lead and iron was found. Body weight was lower in low-lead than lead-supplemented 28-d-old rats regardless of dietary iron, whereas hematocrit and hemoglobin were lower in low-lead than lead-supplemented rats fed 50 micrograms iron/g diet. A similar finding was obtained with hematocrit and hemoglobin in 35-d-old rats. Dietary lead did not affect rats fed 250 or 1000 micrograms iron/g diet. Also, feeding low dietary lead did not affect 50-d-old rats regardless of dietary iron. Liver and bone concentrations of lead were markedly affected by dietary lead and iron. The concentration of lead in liver and bone was lower in low-lead than lead-supplemented rats. Compared to rats fed 50 micrograms iron/g diet, rats fed 250 micrograms iron/g diet exhibited a decreased lead concentration in liver and bone. This decrease was accentuated by...Continue Reading

References

Dec 1, 1975·The Journal of Nutrition·F H NielsenD A Ollerich
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Oct 22, 1971·Nature·K KostialM Pisonić
May 1, 1972·The Journal of Nutrition·G B Forbes, J C Reina
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Dec 1, 1962·The Journal of Nutrition·P N DavisF H Kratzer
Dec 1, 1979·Biological Trace Element Research·F H NielsenE O Uthus

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Citations

Dec 28, 2011·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Koji FujisakiHiroaki Kagi
Nov 13, 2013·Environmental Geochemistry and Health·Ting FangDun Wu
Aug 1, 1994·Journal of the American Dietetic Association·B F Harland, B A Harden-Williams
Sep 1, 1996·Zeitschrift für Ernährungswissenschaft·J EberleM Kirchgessner

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