Abstract
Evidence has implicated oxidative stress (OS) and inflammation as drivers of neurodegenerative pathologies. We previously reported on the beneficial effects of (-)-epicatechin (Epi) treatment on aging-induced OS and its capacity to restore modulators of mitochondrial biogenesis in the prefrontal cortex of 26-month-old male mice. In the present study using the same mouse model of aging, we examined the capacity of Epi to mitigate hippocampus OS, inflammation, hyperphosphorylation of tau protein, soluble β-amyloid protein levels, cell survival, memory, anxiety-like behavior levels and systemic inflammation. Mice were subjected to 4 weeks of Epi treatment (1 mg kg-1 day-1) and samples of the hippocampus were obtained. Assessments of the OS markers, protein carbonyls, and malondialdehyde levels demonstrated their significant increase (∼3 fold) with aging that were partially suppressed by Epi. The protein levels of the glial fibrillary acidic protein, inflammatory factor 1 (Iba1), pro-inflammatory cytokines, interleukins (IL-1β, IL-3, 5, 6 and 15), cyclooxygenase 2, tumor necrosis factor α, nuclear factor-activated B cells and interferon γ increase with aging and were also significantly decreased with Epi treatment. However, anti-in...Continue Reading
References
Aug 28, 1992·Science·E R Stadtman
Aug 16, 1990·Biochemical and Biophysical Research Communications·S IkebeT Ozawa
Aug 5, 2000·The Journal of Nutrition·J F WangC L Keen
Jun 19, 2001·Neuropharmacology·Y Gilgun-SherkiD Offen
Jul 20, 2002·Science·John Hardy, Dennis J Selkoe
May 14, 2003·Experimental Gerontology·Chong Gun ChoHae Young Chung
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Christian HeissMalte Kelm
Oct 14, 2003·Biochemical Pharmacology·Anne EckertWalter E Müller
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
Jun 11, 2004·Journal of the American College of Nutrition·Mary B EnglerMichele L Mietus-Snyder
Aug 18, 2004·Behavioural Brain Research·Vincent Roy, Pierre Chapillon
Jun 7, 2005·Expert Opinion on Drug Safety·James P O'Callaghan, Krishnan Sriram
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hagen SchroeterMalte Kelm
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Naomi D L FisherNorman K Hollenberg
Jun 24, 2006·Journal of Cardiovascular Pharmacology·S T FrancisI A Macdonald
Oct 6, 2006·Neurochemical Research·Zhihao XuWeidong Le
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Dec 20, 2007·Journal of Neurochemistry·Claudie HooperSimon Lovestone
Jan 9, 2008·The British Journal of Nutrition·Jean-François BissonMichaël Messaoudi
Jan 22, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ravichandran SrividhyaPeriandavan Kalaiselvi
Aug 30, 2008·Learning & Memory·Israela BalderasFederico Bermudez-Rattoni
Oct 22, 2008·Genes & Nutrition·David VauzourJeremy P E Spencer
Feb 18, 2011·Physiology & Behavior·David T FieldLaurie T Butler
Jul 12, 2011·Free Radical Biology & Medicine·Akari IshisakaJunji Terao
Jul 21, 2011·Food & Function·Ana FariaConceição Calhau
Jul 27, 2011·The Journal of Physiology·Leonardo NogueiraMoh H Malek
Jul 30, 2011·The Journal of Pharmacology and Experimental Therapeutics·Mary-Louise Middlemore-RisherAlvin V Terry
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ken-ichi NakajimaYoshinori Marunaka
Aug 23, 2012·PloS One·Willem KamphuisElly M Hol
Jun 1, 2013·PloS One·Catarina RendeiroJeremy P E Spencer
Oct 8, 2013·Clinics in Geriatric Medicine·Caroline N HaradaKristen L Triebel
Aug 22, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Aldo Moreno-UlloaIsrael Ramirez-Sanchez
Jan 7, 2015·Translational Psychiatry·T P StringerH van Praag
Feb 14, 2016·Appetite·Georgina E CrichtonAla'a Alkerwi
Mar 20, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Israel Ramírez-SánchezFrancisco Villarreal
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Animesh Alexander RahaRuma Raha-Chowdhury
Sep 1, 2017·Saudi Journal of Biological Sciences·Mohammad S OlaSalim S Al-Rejaie
Feb 2, 2018·Frontiers in Pharmacology·Miroslav DinićJovanka Lukić
Apr 3, 2019·Nutrients·Huong T T PhanMun'delanji C Vestergaard