Effects of (-)-sesamin on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and dopaminergic neuronal cells of Parkinson's disease rat models

Neurochemistry International
Hyun Jin ParkMyung Koo Lee

Abstract

The present study investigated the effects of (-)-sesamin on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity using PC12 cells and dopaminergic neuronal cells of 6-OHDA-lesioned rat model of Parkinson's disease (PD). In PC12 cells, treatment with (-)-sesamin (25 µM) reduced 6-OHDA (100 µM)-induced cell death and induced transient extracellular signal-regulated kinase (ERK1/2) phosphorylation and Bad phosphorylation at Ser112 (BadSer112). In contrast, sustained ERK1/2 phosphorylation, p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK1/2) phosphorylation, and cleaved-caspase-3 activity, all of which were induced by 6-OHDA (100 µM), were inhibited by treatment with (-)-sesamin (25 µM). Furthermore, co-treatment with (-)-sesamin (30 mg/kg, p.o.) once a day for 28 days significantly increased the number of tyrosine hydroxylase-immunopositive neuronal cells and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid in the substantia nigra-striatum of 6-OHDA-lesioned rat model of PD with or without L-DOPA treatment. These results suggest that (-)-sesamin protects 6-OHDA-induced cytotoxicity via the activation of transient ERK1/2-BadSer112 system and the inhibition of...Continue Reading

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Citations

Apr 12, 2017·Archives of Pharmacal Research·Hyun Jin ParkMyung Koo Lee
Dec 21, 2016·Neurochemical Research·Ting Ting ZhaoMyung Koo Lee
Aug 5, 2017·Acta Pharmacologica Sinica·Ying-Liang LiuHeng-Li Tian
Apr 21, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Sasimol UdomrukPrachya Kongtawelert
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ping-Chung KuoSheng-Nan Wu
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet ÖzdemirMiriş Dikmen
Jan 14, 2021·International Immunopharmacology·Shahab GhaderiKhodabakhsh Rashidi
Mar 6, 2019·ACS Chemical Neuroscience·Xuechai ChenJuan Wang

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