Abstract
The present study investigated the effects of (-)-sesamin on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity using PC12 cells and dopaminergic neuronal cells of 6-OHDA-lesioned rat model of Parkinson's disease (PD). In PC12 cells, treatment with (-)-sesamin (25 µM) reduced 6-OHDA (100 µM)-induced cell death and induced transient extracellular signal-regulated kinase (ERK1/2) phosphorylation and Bad phosphorylation at Ser112 (BadSer112). In contrast, sustained ERK1/2 phosphorylation, p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK1/2) phosphorylation, and cleaved-caspase-3 activity, all of which were induced by 6-OHDA (100 µM), were inhibited by treatment with (-)-sesamin (25 µM). Furthermore, co-treatment with (-)-sesamin (30 mg/kg, p.o.) once a day for 28 days significantly increased the number of tyrosine hydroxylase-immunopositive neuronal cells and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid in the substantia nigra-striatum of 6-OHDA-lesioned rat model of PD with or without L-DOPA treatment. These results suggest that (-)-sesamin protects 6-OHDA-induced cytotoxicity via the activation of transient ERK1/2-BadSer112 system and the inhibition of...Continue Reading
References
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 1, 1995·Journal of Nutritional Science and Vitaminology·Y Fujiyama-FujiwaraO Igarashi
Apr 1, 1995·Natural Product Reports·R S Ward
Apr 14, 1994·Neuroreport·T S SmithJ P Bennett
Mar 25, 1994·Cell·B DérijardR J Davis
Jan 1, 1993·Annals of Nutrition & Metabolism·K AkimotoH Yamada
Nov 1, 1993·Neurochemical Research·R AndrewR K Petty
Nov 15, 1996·Cell·J ZhaS J Korsmeyer
Aug 28, 1998·European Journal of Pharmacology·P Izurieta-SánchezY Michotte
Oct 23, 1998·Biochemical Pharmacology·M Merad-BoudiaI Ceballos-Picot
Jul 9, 1999·Journal of Neuroscience Research·W S ChoiY J Oh
Nov 11, 1999·Oncogene·H Ichijo
Apr 12, 2002·Animal Reproduction Science·Ming Yuan Yang, Rajadurai Rajamahendran
Sep 18, 2003·Journal of Neuroscience Research·Rolis Chien-Wei HouKee-Ching G Jeng
Nov 7, 2003·Neurochemistry International·S SánchezF Wandosell
Aug 17, 2004·Neuroscience Letters·Rolis Chien-Wei HouKee-Ching G Jeng
Nov 1, 2005·Brain Research·Himant MaharajSanty Daya
Nov 29, 2005·Journal of Natural Products·Chia-Ying LiTian-Shung Wu
Dec 3, 2005·European Journal of Cell Biology·Hyun Jung LeeSung Su Kim
Mar 15, 2006·Neuroscience Letters·Maddalena NapolitanoAlberto Gulino
Apr 20, 2006·The Journal of Biological Chemistry·Yue Luo, Donald B DeFranco
Sep 12, 2007·Journal of Neuroscience Research·Eva LinMichael J Zigmond
Jul 8, 2008·European Journal of Pharmacology·Chun Mei JinMyung Koo Lee
Jul 31, 2008·Journal of Neurochemistry·Jezabel Rodriguez-BlancoCarmen Rodriguez
Oct 22, 2008·Biochimica Et Biophysica Acta·Talene A Yacoubian, David G Standaert
Jun 18, 2009·Journal of Neural Transmission·Nanako HamadaMasafumi Ito
Jan 30, 2010·Parkinsonism & Related Disorders·M Angela CenciDaniella Rylander
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun Sook ChoiMyung Koo Lee
Mar 12, 2011·Journal of Agricultural and Food Chemistry·Ping-Chung KuoJason T C Tzen
Feb 2, 2012·Neuropharmacology·Min ZhangMyung Koo Lee
Apr 28, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Keun Hong ParkMyung Koo Lee
Citations
Aug 22, 2015·Oxidative Medicine and Cellular Longevity·Lingyan WangXiaomei Yao
Dec 23, 2016·Journal of Medicinal Food·Kyung Sook KimMyung Koo Lee
Apr 12, 2017·Archives of Pharmacal Research·Hyun Jin ParkMyung Koo Lee
Dec 21, 2016·Neurochemical Research·Ting Ting ZhaoMyung Koo Lee
Jul 21, 2017·Nanoscale·Qing GuoChang Ming Li
Aug 5, 2017·Acta Pharmacologica Sinica·Ying-Liang LiuHeng-Li Tian
Aug 25, 2019·Science China. Life Sciences·Junchi ZhangJingshan Shen
Apr 25, 2018·Molecular Neurobiology·Yuan XuYing Xia
Apr 21, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Sasimol UdomrukPrachya Kongtawelert
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ping-Chung KuoSheng-Nan Wu
Jan 16, 2016·Human Molecular Genetics·Maya DonyoGil Ast
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet ÖzdemirMiriş Dikmen
Mar 1, 2020·The FEBS Journal·Xi ChenWei-Jia Kong
Nov 10, 2020·Nutritional Neuroscience·Bo ChenJing An
Jan 14, 2021·International Immunopharmacology·Shahab GhaderiKhodabakhsh Rashidi
Mar 6, 2019·ACS Chemical Neuroscience·Xuechai ChenJuan Wang
Oct 14, 2020·Journal of Ethnopharmacology·Eman A MohamedAmira M Badr