Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response

International Journal of Endocrinology
Jeremy R TownsendJeffrey R Stout

Abstract

Objective. To examine the endocrine response to a bout of heavy resistance exercise following acute β-hydroxy-β-methylbutyrate free acid (HMB-FA) ingestion. Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule. Results. The resistance exercise protocol resulted in significant elevations from PRE in testosterone (P < 0.01), GH (P < 0.01), and insulin (P = 0.05) at IP, with GH (P < 0.01) and insulin (P < 0.01) remaining elevated at 30P. A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01). AUC analysis revealed an elevated GH and IGF-1 response in the HMB-FA group compared to PL. Conclusion. HMB-FA prior to resistance exercise augments the GH response to high volume r...Continue Reading

References

Mar 1, 1979·Acta Endocrinologica·P Bratusch-Marrain, W Waldhäusl
Oct 1, 1976·Journal of Applied Physiology·J Sutton, L Lazarus
Jan 1, 1981·Current Medical Research and Opinion·A IsidoriM Cappa
Sep 1, 1993·International Journal of Sport Nutrition·G M FogelholmM H Härkönen
Mar 1, 1997·International Journal of Sport Nutrition·R R SuminskiK F Metz
Aug 13, 1999·Journal of Applied Physiology·C J PritzlaffA Weltman
Nov 6, 2003·Medicine and Science in Sports and Exercise·Jay R HoffmanBarry A Speiring
Apr 6, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Scott R CollierJill A Kanaley
Apr 7, 2009·Medicine and Science in Sports and Exercise·William J KraemerCarl M Maresh
Oct 6, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Archana VijayakumarDerek LeRoith
Jul 8, 2010·Amino Acids·Nelo Eidy ZanchiAntonio Herbert Lancha
Jan 18, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F Gerlinger-RomeroM T Nunes
Feb 5, 2013·Journal of the International Society of Sports Nutrition·Jacob M WilsonJose Antonio
Feb 7, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adam M GonzalezJay R Hoffman
Aug 21, 2014·Journal of the American College of Nutrition·William J KraemerCarl M Maresh
May 1, 1985·The Physician and Sportsmedicine·A S Jackson, M L Pollock

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Citations

Feb 13, 2016·Canadian Journal of Physiology and Pharmacology·Maha H SharawyNariman M Gameil
Oct 12, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michael J ReddIshay Ostfeld
Feb 7, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Mariëlle P K J Engelen, Nicolaas E P Deutz
Feb 9, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ana Luiza Matias CorreiaRicardo Moreno Lima
Jan 4, 2019·European Journal of Nutrition·Pedro L ValenzuelaAlejandro Lucia

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