Abstract
Our previous study indicated that 071031B, a novel potential serotonin and norepinephrine reuptake inhibitor, showed robust antidepressant activity in multiple depression models, and could simultaneously inhibit 5-HT and NE reuptake in vitro. The present study was to evaluate the effects of 071031B on monoamine system in vivo, by using pharmacological models, including 5-HTP induced head-twitch test, yohimbine toxicity potentiation test, and reserpine induced hypothermia test, and determining monoamine transmitter levels in reserpine induced monoamine depletion model or chronic unpredictable stress (CUS) model. Results in pharmacological models indicated that acute administration of 071031B at 5-20 mg/kg significantly enhanced 5-HTP induced head-twitch behavior, potentiated yohimbine induced lethal rate, and reversed reserpine induced hypothermia. Further monoamine assays demonstrated that acute or chronic administration of 071031B at 10 or 20 mg/kg increased 5-HT and/or NE levels in various brain regions in reserpine or CUS induced monoamine depletion models, respectively, without effect on DA and its metabolites. Our results revealed that 071031B produces potent inhibition of 5-HT and NE reuptake in vivo.
References
Feb 17, 1978·Brain Research·O LindvallI Divac
Jan 1, 1980·Psychopharmacology·I P Lapin
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J KatzB J Carroll
Jul 23, 1993·Neuroscience Letters·D R GehlertD W Robertson
Apr 1, 1997·Brain Research. Brain Research Reviews·R MongeauC de Montigny
May 14, 1999·British Journal of Pharmacology·E RivasJ A Fontenla
Mar 29, 2002·Psychopharmacology·Frank P BymasterKenneth W Perry
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·S J CORNEB T WARNER
Nov 24, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Anders D WestanmoRobert Haight
Mar 28, 2008·Pharmacology, Biochemistry, and Behavior·Lei AnYun-Feng Li
Aug 30, 2008·Neurochemical Research·Katsumasa MuneokaSeiji Shioda
Nov 13, 2008·Pharmacology, Biochemistry, and Behavior·Mohit Kumar BhutaniShrinivas K Kulkarni
May 16, 2009·Journal of Pharmacological Sciences·Sandra VezmarMilena Pokrajac
Jul 4, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rui XueYou-Zhi Zhang
Apr 11, 2013·Neuroscience Letters·Rui XueYun-Feng Li
Apr 15, 2014·British Journal of Pharmacology·B Guardiola-LemaitreE Mocaër
Sep 1, 2015·Journal of Pharmacological Sciences·Rui XueYou-Zhi Zhang
Citations
Jul 19, 2016·Acta Pharmacologica Sinica·Ting-Ting ZhangYou-Zhi Zhang
Apr 30, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zhi-Kun QiuYun-Feng Li
Sep 1, 2015·Journal of Pharmacological Sciences·Rui XueYou-Zhi Zhang
Mar 13, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zeng-liang JinYu Tang
May 28, 2019·BioMedicine·Yuh-Tzy LinYuh-Fung Chen
Jun 9, 2018·Journal of Neuroinflammation·Ting-Ting ZhangYou-Zhi Zhang
Jan 23, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qi ShenZhu Luo
Jan 29, 2020·Pharmacology & Therapeutics·Yun-Feng Li
Aug 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao-Le WangYi Zhang