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Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities

Journal of Medicinal Chemistry

Jul 1, 1981

T Viswanathan, W L Alworth

PMID: 7277387

Abstract

The inhibitions of cytochrome P-450 dependent monooxygenase activity in microsomes from rat liver by 1-phenylpyrrole, 1-(2-isopropylphenyl)pyrrole, 4(5)-phenylimidazole, and 1-(2-isopropylphenyl)imidazole have been compared. The results establish that the presence of an imidazole N-3 ni...read more

Mentioned in this Paper

20-Methylcholanthrene
Bioflavonoids
4(5)-phenylimidazole
beta-Naphthoflavone
Microsomes
Cytochrome P450
Methylcholanthrene
Cytochrome P-450 CYP1A2
Oxidase
Monooxygenase Activity
Paper Details
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Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities

Journal of Medicinal Chemistry

Jul 1, 1981

T Viswanathan, W L Alworth

PMID: 7277387

DOI:

Abstract

The inhibitions of cytochrome P-450 dependent monooxygenase activity in microsomes from rat liver by 1-phenylpyrrole, 1-(2-isopropylphenyl)pyrrole, 4(5)-phenylimidazole, and 1-(2-isopropylphenyl)imidazole have been compared. The results establish that the presence of an imidazole N-3 ni...read more

Mentioned in this Paper

20-Methylcholanthrene
Bioflavonoids
4(5)-phenylimidazole
beta-Naphthoflavone
Microsomes
Cytochrome P450
Methylcholanthrene
Cytochrome P-450 CYP1A2
Oxidase
Monooxygenase Activity

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Oxygenation & Hydroxylation

Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.

Mechanisms of CYP450

Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.

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Paper Details
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