Effects of 10-T static magnetic field on human peripheral blood immune cells

Radiation Research
Hiroshi OnoderaYasuto Itoyama

Abstract

The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 type chemokine receptor, CXCR3, and Th2 type receptor, CCR3, was unaltered after magnetic-field exposure. No differences were observed in the naive T cells and memory T-cell subclasses in either CD4(+) or CD8(+) T cells. In contrast to the unstimulated condition, the magnetic-field exposure reduced the viability of phytohemagglutinin (PHA)-activated T cells in both the CD4(+) and CD8(+) subclasses. In particular, the number of PHA-treated naive CD8(+) T cells (CD45RA(+)CD4(-)CD8(+)) was markedly decreased after the magnetic-field exposure, while PHA-treated memory CD8(+) cells (CD45RA(-)CD4(-)CD8(+)) were resistant to the exposure. The number of PHA-treated naive CD4(+) T cells (CD45RA(+)CD4(+)CD8(-)) and memory cells (CD45RA(-)CD4(+)CD8(-)) was markedly decreased to a similar degree. Thus the susceptibility of lymphocytes to the magnetic-field exposure differed among activated T-cell subtypes. The magnetic-field expo...Continue Reading

References

Jan 1, 1983·Bioelectromagnetics·E RamírezJ M Delgado
Mar 1, 1996·Clinical and Experimental Immunology·L LanzaF Indiveri
Nov 20, 1997·Biochimica Et Biophysica Acta·M M BornerM A Hotz
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Jul 8, 1998·Bioscience Reports·B OlejV M Rumjanek
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M DenegreK L Mowry
Feb 19, 2000·Journal of Photochemistry and Photobiology. B, Biology·P WaliszewskiH Minikowski
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
Dec 5, 2000·Bioelectromagnetics·J R GrayJ D Parker
Dec 21, 2000·Bioelectromagnetics·R EmuraT Takeuchi

❮ Previous
Next ❯

Citations

Oct 22, 2010·International Journal of Radiation Biology·János F LászlóRóbert Pórszász
Dec 26, 2006·International Journal of Hygiene and Environmental Health·M SchwenkR Klein
Mar 16, 2016·Progress in Biophysics and Molecular Biology·Wendell Wagner Campos AlbuquerqueAna Lúcia Figueiredo Porto
Nov 24, 2004·Progress in Biophysics and Molecular Biology·Junji Miyakoshi
Feb 4, 2006·Nitric Oxide : Biology and Chemistry·Marcella RealeSilvano Di Luzio
Sep 7, 2007·Osteoarthritis and Cartilage·C-H HsiehC-C Jiang
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Nina F SchwenzerEnno Rodegerdts
Mar 2, 2019·International Journal of Radiation Biology·Amir JalaliMohammad Javad Khodayar
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chantal CourtemancheBruce N Ames

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis