Effects of 10 to 30 years of lithium treatment on kidney function

Journal of Psychopharmacology
Harald AiffJan Svedlund

Abstract

Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980. We retrieved serum lithium and creatinine levels from 4879 patients examined between 1 January 1981 and 31 December 2010. Only patients who started their lithium treatment during the study period and had at least 10 years of cumulative treatment were included. The study group comprised 630 adult patients (402 women and 228 men) with normal creatinine levels at the start of lithium treatment. There was a yearly increase in median serum creatinine levels already from the first year of treatment. About one-third of the patients who had taken lithium for 10-29 years had evidence of chronic renal failure but only 5% were in the severe or very severe category. The results indicate that a substantial proportion of adult patients who are treate...Continue Reading

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Citations

Apr 14, 2016·International Journal of Bipolar Disorders·Scott MonteithMichael Bauer
Nov 19, 2015·Journal of the American Society of Nephrology : JASN·Mohammad AlsadyTheun de Groot
Dec 17, 2009·L'Encéphale·V Le RoyH Verdoux
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Jun 14, 2018·Journal of Psychopharmacology·Mihaela GolicJan Svedlund
Apr 2, 2019·Journal of Clinical Psychopharmacology·Milan DastychJana Gottwaldová
Oct 20, 2019·Bipolar Disorders·Qin Xiang NgVivekanandan Sivalingam
Apr 7, 2020·American Journal of Physiology. Renal Physiology·Yang DuYue Zhang
Oct 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui BaoRujun Gong
May 14, 2020·The International Journal of Neuropsychopharmacology·Rachael W TaylorAnthony J Cleare
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Dec 3, 2016·International Journal of Bipolar Disorders·Michael Gitlin
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May 10, 2017·International Journal of Bipolar Disorders·Leonardo TondoRoss J Baldessarini
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Jul 15, 2020·Journal of Psychopharmacology·Mihaela GolicJan Svedlund
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Jan 5, 2021·International Journal of Bipolar Disorders·Arjan M Van AlphenRocco Hoekstra
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Jul 22, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Wei-Lun LiuHeng-Liang Lin
Jan 4, 2022·Journal of Psychosocial Nursing and Mental Health Services·Karan Kverno

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