Effects of 12-months treatment with zoledronate or teriparatide on intima-media thickness of carotid artery in women with postmenopausal osteoporosis: A pilot study

International Journal of Immunopathology and Pharmacology
E PasseriS Corbetta

Abstract

Atherosclerosis and osteoporosis are interrelated entities and share similar pathogenic mechanisms. Recent studies showed that key proteins of bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), are also involved in vascular atherosclerosis and calcifications. The carotid intima-media thickness (CA-IMT) is an early quantitative marker of generalized atherosclerosis. Aim of study was to investigate whether 12-months treatment with zoledronate (ZLN) or teriparatide (TPT) affects CA-IMT and circulating OPG and OPN levels. In this study, 11 postmenopausal osteoporotic women (aged 73, 70.5-74.5 years; median, range interquartile) treated with 5 mg/year iv ZLN; 9 postmenopausal osteoporotic women (aged 70, 62.5-73.5 years) treated with 20 µg/day sc TPT; and 10 aged-, body mass index (BMI)-, glycemic, and lipid profiles-matched, free from anti-osteoporotic and hypocholesterolemic drugs, controls were prospectively investigated at baseline and after 12 months. At baseline, median CA-IMT was similar in the three groups and increased after 12 months. CA-IMT increased significantly in TPT-treated patients (1.0, 0.8-1.2 vs 1.1, 0.9-15 mm, P = 0.04), though the change was minimal. After 12 months of treatment, CA-IMT posit...Continue Reading

References

Feb 16, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A D AnastasilakisA Avramidis
Jul 29, 2008·International Journal of Clinical Practice·H S ChoiS-K Lim
Sep 17, 2009·The Journal of Clinical Endocrinology and Metabolism·M D WalkerS J Silverberg
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Marco Matteo CicconeSalvatore Novo
Apr 18, 2015·PloS One·Dae Hyun KimSeoyoung C Kim
Jul 9, 2016·Vascular Pharmacology·Cristina Vassalle, Annamaria Mazzone
Nov 15, 2017·Clinical Interventions in Aging·Carla CaffarelliStefano Gonnelli

❮ Previous
Next ❯

Citations

Feb 10, 2021·Calcified Tissue International·Gabriella IannuzzoDomenico Rendina

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
X-ray
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad
PRISM

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.