Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers in rats

Japanese Journal of Pharmacology
Y OnodaH Tamaki

Abstract

Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers were investigated in rats. Oral administration of TA-2711 at doses of 25 to 100 mg/kg immediately after pyloric ligation markedly reduced pepsin activity and slightly lowered acid concentration without affecting the volume of gastric juice. Addition of TA-2711 (0.25-16 mg/ml) directly to gastric juice also reduced pepsin activity in vitro. Oral TA-2711 dose-relatedly inhibited the formation of pylorus-ligated ulcers (50-200 mg/kg), aspirin-induced gastric erosions (25-100 mg/kg) and cysteamine-induced duodenal ulcers (100-800 mg/kg). In addition, this drug prevented both the formation of gastric lesions (6.3-100 mg/kg, p.o.) and the fall in gastric potential difference (100 mg/kg, p.o.) induced by ethanol. The preventive effect against ethanol-induced lesions was suppressed by pretreatment with indomethacin (10 mg/kg, s.c.). Intravenous dosing of TA-2711 (10-100 mg/kg) never produced such effects on ethanol-induced lesions and pepsin activity as observed by oral administration. These results indicate that TA-2711 exerts its anti-ulcer effect by a local action, and it is suggested that both reduc...Continue Reading

Citations

Jan 30, 1999·The British Journal of Ophthalmology·M NakamuraT Hamano
May 26, 1998·European Journal of Pharmacology·Y ItoM Kinoshita
Mar 15, 2006·Digestive Diseases and Sciences·Kenji NagahamaKoji Takeuchi
Jun 30, 2005·Journal of Ethnopharmacology·Guillermo Schmeda-HirschmannTania Yáñez
Feb 9, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dan ZhangJingkai Gu
Feb 2, 2008·World Journal of Gastroenterology : WJG·Hyung Wook KimGeun Am Song
Jul 22, 2014·Journal of Animal Physiology and Animal Nutrition·M P TurskiP Paluszkiewicz
Nov 4, 2009·Scandinavian Journal of Gastroenterology·Kazuto TsuboiKatsuhiko Yanaga

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