Effects of 14-methoxymetopon, a potent opioid agonist, on the responses to the tail electric stimulation test and plus-maze activity in male rats: neuroendocrine correlates

Brain Research Bulletin
Leyre UrigüenMaria Paz Viveros

Abstract

We have studied the effects of 14-methoxymetopon (HS 198), a potent opioid agonist, on the responses to the tail electric stimulation test and plus-maze activity of adult male rats. The prototype mu agonist morphine was used as the drug of reference. Besides we addressed the effects of HS 198 on the serum corticosterone levels and on serotonergic systems of discrete brain regions. Both drugs were administered subcutaneously. Morphine (5 mg/kg) and HS 198 (30 microg/kg) induced a similar effect on the nociceptive test, with both drugs significantly increasing the threshold for the vocalization afterdischarge, which is related to the emotional component of pain. In the plus-maze, morphine (5 mg/kg) and HS 198 (20 and 30 microg/kg) induced similar increases in the percentages of entries and time in the open arms, two parameters related to the anxiety state of the animals. The results indicate that HS 198 is far more potent than morphine in reducing the emotive/affective component of pain and in inducing an anxiolytic effect. HS 198 (30 microg/kg) also induced parallel increases in the serum corticosterone levels and the hypothalamic serotonin content. A possible correlation between the anxiolytic action of the drug and its effect ...Continue Reading

References

Nov 1, 1975·European Journal of Pharmacology·M SimonJ Garcia
Jun 21, 1990·European Journal of Pharmacology·J Antonio MartínezM V Milanés
Jan 1, 1990·Pharmacology & Therapeutics·H Anisman, R M Zacharko
Jan 1, 1986·Physiology & Behavior·C Kinsley, B Svare
May 1, 1986·Pharmacology, Biochemistry, and Behavior·D A Peters
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·C de Cabo de la VegaM Paz Viveros
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·A PujolM P Viveros
May 19, 1993·European Journal of Pharmacology·Z FürstA Borsodi
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
May 1, 1996·Pharmacology, Biochemistry, and Behavior·F G GraeffJ F Deakin
Sep 19, 1996·European Journal of Pharmacology·O ValverdeR Maldonado
May 8, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M L PriceI Lucki
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·S E FileS Cheeta
Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Feb 22, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·W SommerM Heilig

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Mar 7, 2003·Neurochemistry International·Monica De la FuenteMaria Paz Viveros
Dec 15, 2015·European Journal of Medicinal Chemistry·Rita TurnaturiLorella Pasquinucci
Jul 31, 2003·The European Journal of Neuroscience·Mariana SpeteaHelmut Schmidhammer
Jul 6, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mariana SpeteaHelmut Schmidhammer
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Jan 1, 2012·International Journal of Medicinal Chemistry·Helmut Schmidhammer, Mariana Spetea
Sep 5, 2003·Journal of Medicinal Chemistry·Johannes SchützHelmut Schmidhammer
Oct 4, 2011·Neuroscience·O Valverde, M Torrens

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