Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia

Intensive Care Medicine
Balázs HauserHendrik Bracht

Abstract

To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. Prospective, randomized, controlled experimental study with repeated measures. Investigational animal laboratory. 19 anesthetized, mechanically ventilated and instrumented pigs. At 12 h of continuous intravenous endotoxin and hydroxyethylstarch to keep mean arterial pressure (MAP)>60 mmHg, swine randomly received vehicle (control group, n=10) or 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2 group, n=9; 1 microg kg(-1) min(-1) loading dose during 1 h; thereafter,0.25 microg kg(-1) min(-1) for 11 h). Hemodynamic, metabolic and organ function parameters were assessed together with parameters of nitric oxide production and oxidative stress. 15d-PGJ2 prevented the endotoxin-induced progressive hypotension, due to a positive inotropic effect, which resulted in a significantly higher blood pressure during the treatment phase and prevented the rise in hepatic vein alanine-aminotransferase activity. It did not affect, however, any other parameter of organ function nor of nitr...Continue Reading

References

Jan 7, 1999·Intensive Care Medicine·H Böhrer, P P Nawroth
Jun 17, 1999·Nature Medicine·D W GilroyD A Willoughby
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R ThieringerJ Berger
Mar 1, 2000·British Journal of Pharmacology·D Bishop-Bailey
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S B HaudekB P Giroir
Mar 30, 2001·The Journal of Biological Chemistry·M KondoK Uchida
Jan 10, 2002·Critical Care Medicine·Uwe Senftleben, Michael Karin
May 29, 2002·Cardiovascular Research·Domenica AltavillaFrancesco Squadrito
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicole S WaymanChristoph Thiemermann
Oct 3, 2002·Nature Reviews. Immunology·Toby LawrenceDerek W Gilroy
Jan 25, 2003·Critical Care Medicine·Basilia ZingarelliHector R Wong
Jul 25, 2003·Intensive Care Medicine·Salvatore CuzzocreaChristoph Thiemermann
Sep 5, 2003·Intensive Care Medicine·Uwe Senftleben
Sep 13, 2003·European Journal of Pharmacology·Marika Collin, Christoph Thiemermann
Feb 14, 2004·Cardiovascular Research·Prabal Kumar ChatterjeeChristoph Thiemermann

❮ Previous
Next ❯

Citations

Dec 20, 2007·Critical Care Medicine·Eberhard BarthEnrico Calzia
Apr 24, 2008·Critical Care Medicine·William J Ehlenbach, J Randall Curtis
Jan 15, 2011·Journal of Leukocyte Biology·Lynsey FairbairnDavid A Hume
Jan 9, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Katsutaka WatanabeMasato Nagino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.