Effects of 16, 16-dimethyl prostaglandin E2 methyl ester on aspirin-and indomethacin-induced gastrointestinal lesions in dogs

Digestive Diseases and Sciences
K Tabata, S Okabe

Abstract

The pathogenesis of aspirin- or indomethacin-induced gastric and/or intestinal lesions was studied in dogs. 16,16-Dimethyl PGE2 methyl ester (16-DMPGE2) at 2 or 10 microgram/kg in two divided doses given intramuscularly markedly inhibited gastric lesions produced by orally ingested aspirin at 200 mg/kg/day given twice daily for 1 or 5 days. While 16-DMPGE2 at the same dose also inhibited gastric lesions induced by a single oral administration of indomethacin at 20 mg/kg, gastric lesions including deep antral ulcers, produced by repeated administration of indomethacin, were not affected. Intestinal lesions produced by indomethacin given once, or for 5 or 10 days, were not affected. These results suggest that the lack of engoenous prostaglandins may be involved in the pathogenesis of gastric lesions produced by aspirin and indomethacin given once but may not be involved in the pathogenesis of indomethacin-induced deep lesions in the stomach and intestine.

References

Jun 1, 1983·Digestive Diseases and Sciences·Y IshiharaS Okabe
Apr 1, 1984·Digestive Diseases and Sciences·K TabataS Okabe
May 6, 1983·European Journal of Pharmacology·M Maeda-Hagiwara, K Watanabe
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Kenichi NonoyamaSusumu Okabe

Citations

Feb 1, 1976·The American Journal of Physiology·A A MihasB I Hirschowitz
Oct 1, 1978·Canadian Journal of Physiology and Pharmacology·B L TeppermanE D Jacobson
Sep 1, 1977·The American Journal of Digestive Diseases·W F FangE D Jacobson
Feb 1, 1969·The Journal of Pharmacy and Pharmacology·A SomogyiH Selye
Mar 1, 1966·Clinical Pharmacology and Therapeutics·C DavisonR DeVine
Nov 1, 1970·Toxicology and Applied Pharmacology·D A BrodieG E Dagle
Sep 1, 1967·The American Journal of Digestive Diseases·R Menguy, L Desbaillets

Related Concepts

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