Effects of 16,16-dimethyl prostaglandin E2 on alkaline secretion in isolated canine gastric mucosa

Digestive Diseases and Sciences
Y J KuoT A Miller


An isolated fundic mucosal preparation of dog stomach which is capable of exhibiting an alkaline secretion is described. A stable secretion was established 40 min to 1 hr after the mucosa was pretreated with the H2-antagonist cimetidine to block spontaneous acid output. Alkaline secretion decreased when Ca2+ was removed from the nutrient solution. This secretion was stimulated by dibutyryl cyclic GMP, but was not altered by acetylcholine, carbachol, or 16,16-dimethyl PGE2. Alkaline secretion from a similar antral mucosal preparation was stimulated by 16,16-dimethyl PGE2. We conclude that the 16,16-dimethyl PGE2-stimulated bicarbonate secretion previously demonstrated in in vivo canine fundic mucosa is not the result of a direct effect of PG on gastric mucosal cells and that an intact blood circulation or cholinergic innervation is required for this action to occur.


Jun 1, 1979·The Journal of Physiology·Y J Kuo, L L Shanbour
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A Haymovits, G A Scheele
Jul 1, 1977·The American Journal of Physiology·Y Matsumoto, A M McPhedran
Jan 1, 1979·Gut·T A Miller, E D Jacobson
Oct 1, 1978·Canadian Journal of Physiology and Pharmacology·B L TeppermanE D Jacobson
Dec 1, 1978·The Journal of Physiology·Y J Kuo, L L Shanbour
Jan 1, 1972·Pflügers Archiv : European journal of physiology·S Dai, C W Ogle
Apr 1, 1974·The American Journal of Digestive Diseases·L L Shanbour
Nov 1, 1969·The American Journal of Physiology·T J Sernka, C A Hogben

Related Concepts

Dibutyryl Cyclic GMP
Canis familiaris
Structure of Pyloric Gland
Hydrogen-Ion Concentration
Prostaglandins E, Synthetic
16,16-Dimethylprostaglandin E2
In Vitro [Publication Type]

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