Effects of 17beta-estradiol on glutamate synaptic transmission and neuronal excitability in the rat medial vestibular nuclei

Neuroscience
S GrassiV E Pettorossi

Abstract

We investigated the effects of the neurosteroid 17beta-estradiol (E(2)) on the evoked and spontaneous activity of rat medial vestibular nucleus (MVN) neurons in brainstem slices. E(2) enhances the synaptic response to vestibular nerve stimulation in type B neurons and depresses the spontaneous discharge in both type A and B neurons. The amplitude of the field potential, as well as the excitatory post-synaptic potential (EPSP) and current (EPSC), in type B neurons, are enhanced by E(2). Both effects are long-term phenomena since they outlast the drug washout. The enhancement of synaptic response is mainly due to facilitation of glutamate release mediated by pre-synaptic N-methyl-D-aspartate receptors (NMDARs), since the reduction of paired pulse ratio (PPR) and the increase of miniature EPSC frequency after E(2) are abolished under D-(-)-2-amino-5-phosphonopentanoic acid (AP-5). E(2) also facilitates post-synaptic NMDARs, but it does not affect directly alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) and group I-metabotropic glutamate receptors (mGluRs-I). In contrast, the depression of the spontaneous discharge of type A and type B neurons appears to depend on E(2) modulation of intrinsic ion conduct...Continue Reading

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Citations

Jul 13, 2012·Cerebral Cortex·Xiao XiaoYu-Qiu Zhang
Aug 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Mayank B Dutia
Mar 23, 2011·Neurochemistry International·Andreas PlaitakisCleanthe Spanaki
Apr 17, 2016·Journal of Neurology·Michel LacourPierre-Paul Vidal
Feb 19, 2011·Experimental Brain Research·Daniel EugènePierre-Paul Vidal
May 13, 2020·International Journal of Molecular Sciences·Cristina V DieniRoberto Panichi
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

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