PMID: 9643447Jun 27, 1998Paper

Effects of 17beta-oestradiol on rat isolated coronary and mesenteric artery tone: involvement of nitric oxide

The Journal of Pharmacy and Pharmacology
D Otter, Clare Austin

Abstract

Pre- and post-menopausal women receiving oestrogen replacement therapy have a significantly reduced risk of cardiovascular disorders. It has been suggested that this protection might be partly a result of a direct relaxant effect of oestrogens on coronary arteries. This study examines and directly compares the effects of 17beta-oestradiol on rat isolated coronary and mesenteric vessels. The influence of nitric oxide on these responses was also investigated. 17Beta-oestradiol caused similar concentration-dependent relaxation of isolated coronary and mesenteric resistance arteries pre-contracted with either KCl (60 mM) or 9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin (U46619; 1 microM). The relaxation responses to 17beta-oestradiol were significantly reduced, but not totally inhibited, in the presence of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase; they were not altered by indomethacin, an inhibitor of prostaglandin synthesis. The responses to 17beta-oestradiol in the presence of L-NAME were not dependent on the vessel studied or the pre-contracting agent used. These results suggest that nitric oxide might contribute to the vasodilatory effects of 17beta-oestradiol in rat isolate...Continue Reading

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Citations

Dec 15, 2005·Heart, Lung & Circulation·L BrownS A Doggrell
Oct 22, 2003·Climacteric : the Journal of the International Menopause Society·C O LundB Ottesen
Aug 2, 2003·British Journal of Pharmacology·Sandra MontgomeryClare Austin
Jun 30, 2007·Clinical and Experimental Pharmacology & Physiology·Ricky Y K Man, Susan W S Leung
Apr 27, 2007·Vascular Pharmacology·Pei-Han XuZhong-Li Liu
Mar 30, 2017·Prostaglandins & Other Lipid Mediators·G Ozen, X Norel
Nov 1, 2000·Journal of Hypertension·C E Austin
Mar 27, 2003·Current Opinion in Critical Care·Eugene P CeppaGregory B Bulkley
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Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·R J Gonzales, N L Kanagy

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