Effects of 1alpha,25-dihydroxyvitamin D3 and Solanum glaucophyllum on intestinal calcium and phosphate transport and on plasma Ca, Mg and P levels in the rat

Endocrinology
M W Walling, D V Kimberg

Abstract

The responses elicited by a single dose of either S. glaucophyllum (SG) or 1alpha,25-dihydroxyvitamin D3 (1alpha, 25-(OH)2D3) in vitamin D-deficient rats were qualitatively identical. Both compounds stimulated duodenal absorption of calcium and phosphate 3 h after administration, and the effects persisted for 96 h. The SG effects on calcium transport were maximal at 6 h and exceeded the greatest response to 1alpha,25-(OH)2D3 which occurred at 48 h. While the early SG effects on phosphate absorption exceeded those of 1alpha,25-(OH)2D3, the latter compound had a much greater effect at 48 h. Both SG and 1alpha, 25-(OH)2D3 produced marked hyperphosphatemia that was accompanied by hypocalcemia and transient hypermagnesemia at 3-6 h. The phosphatemia increased for 48 h in the 1alpha,25-(OH)2D3 group and fell toward baseline between 48 and 96 h, while this parameter was maximal in the SG group at 3-12 h and returned to baseline values by 96 h. Plasma calcium levels tended to vary inversely with phosphorus concentrations and did not exceed baseline values until 48 h for the SG group and 96 h for the 1alpha,25-(OH)2D3 group. We suggest that the hypocalcemia is due to calcium phosphate precipitation. The quantitative differences in the e...Continue Reading

Citations

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