Effects of β2-Adrenergic Agonists on Risk of Parkinson's Disease in COPD: A Population-Based Study.

Pharmacotherapy
Wenjia ChenMahyar Etminan

Abstract

Multiple studies have investigated the role of β2 -adrenoreceptor agonists on the risk of Parkinson's disease (PD). However, whether β2 -agonist use is associated with the risk of PD in patients with chronic obstructive pulmonary disease (COPD) has not been examined to date. To examine the association between use of β2 -agonist and the risk of PD in patients with COPD. A case-control study nested within a cohort of patients with COPD using the British Columbia health administrative databases from 1997 to 2015 was performed. Among a cohort of patients with COPD, all cases of PD were identified, and matched each case to up to five controls by age and calendar time. The use of β2 -agonists was assessed between the third and fourth year preceding the date of PD diagnosis, followed by additional two years of grace period (between the first and second year preceding PD incidence) to control for PD latency. The use of β2 -agonists was categorized into three levels: regular use (≥ 1 dispensation for every 6 months), irregular use (dispensation in one to three 6-month periods), and no use. A conditional logistic regression model was used to estimate the rate ratio of PD according to β2-agonist use, rigorously controlling for confounding...Continue Reading

References

Oct 18, 2003·American Heart Journal·Vidal EssebagLouise Pilote
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Nov 20, 2004·Occupational and Environmental Medicine·D B Richardson
Apr 19, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Kari SwarztrauberDawn Peters
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Lee Clough, Leonidas Stefanis
Jan 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Eric M ChengBarbara G Vickrey
Sep 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Nicholas R Szumski, Eric M Cheng
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Lisa M Shulman
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Mario CazzolaM Gabriella Matera
Jul 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Tamara PringsheimThomas D L Steeves
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Naomi GronichWalid Saliba

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