Effects of β2 agonists on post-thoracotomy pain incidence

European Journal of Pain : EJP
Eric SalvatMichel Barrot

Abstract

Pre-clinical research has shown β2 -adrenoceptors to be essential for the antiallodynic action of antidepressant drugs in murine models of neuropathic pain and that sustained treatment with β2 -agonists has an antiallodynic action. Here, we clinically investigated whether chronic β2 -agonist treatments may influence the incidence of post-thoracotomy chronic pain, defined as pain that recurs or persists along a thoracotomy scar more than 2 months after surgery, either neuropathic or non-neuropathic. We conducted an epidemiological study on patients operated by thoracotomy. Demographic data, medical history and treatments concomitant to the surgery were recorded at a follow-up visit. Information on perioperative treatments was collected from the anaesthesia records and confirmed by the patients. In patients with pain at the surgery level, post-thoracotomy chronic pain was assessed by clinical examination and numeric scale. Physical examination and DN4 questionnaire were used to discriminate neuropathic and non-neuropathic chronic pain at scar level. One hundred and eighty-nine patients were included. Eighty-one patients reported persisting thoracic pain, with neuropathic characteristics in 58 of them (30% of the 189 patients). Th...Continue Reading

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Citations

Nov 8, 2015·The Journal of Pain : Official Journal of the American Pain Society·Vipin AroraChristopher M Peters
Nov 25, 2016·Current Medical Research and Opinion·Ulderico FreoFrancesco Ambrosio
Mar 3, 2020·Frontiers in Molecular Neuroscience·Rhian Alice CeredigDominique Massotte
Jun 19, 2019·Revue des maladies respiratoires·G BrioudeX B D'Journo

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