PMID: 3773528Oct 1, 1986Paper

Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat

Journal of Steroid Biochemistry
A ValetteJ Boyer

Abstract

Biological activities of estrogen molecules are altered by fluorination of ring A, and the resulting impairment to form catechols. 2-fluoroestradiol (2-F-E2) has been found to be devoid of carcinogenic action despite its high estrogenic potency; its metabolic effects are so far unknown. This study was designed to investigate the effects of 2-F-E2 on lipid metabolism, as compared to those of estradiol-17 beta(E2). Ovariectomized rats received E2 or 2-F-E2 by s.c. injection at a dose of 60 micrograms for three consecutive days. Parameters measured were weights of parametrial fat depots, fat cell volumes, levels of triacylglycerol and acylcholesterol in plasma, and enzymatic responses to the estrogens in isolated parametrial fat cells as evaluated in terms of lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL) activities. 2-F-E2 and E2 were found to produce comparable decreases in fat depots, cell volumes and plasma levels of acylcholesterol whereas plasma triacylglycerol was unchanged. Both estrogens decreased LPL, and increased HSL activities to the same extent. Thus, 2-F-E and E2 exhibited comparable effects on lipid metabolism. These effects appeared to depend mainly on the estrogenic potency of these molecules, and to...Continue Reading

References

Mar 1, 1978·Journal of Toxicology and Environmental Health·E C HorningE D Helton
May 1, 1975·The Journal of Clinical Investigation·M Hamosh, P Hamosh
Sep 1, 1986·Chemico-biological Interactions·J G LiehrA A Ulubelen
Sep 1, 1973·Endocrinology·J MénardJ P Raynaud
Sep 7, 1972·Biochimica Et Biophysica Acta·M L WatkinsM Heimberg
Mar 1, 1983·Molecular and Cellular Endocrinology·A ValetteJ Boyer
Jan 1, 1980·Annual Review of Biochemistry·P Nilsson-EhleM C Schotz
Dec 31, 1982·Biochemical and Biophysical Research Communications·V BenoitJ Boyer
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·J BoyerJ Arnaud
Dec 15, 1981·Biochemical and Biophysical Research Communications·P SalersJ Boyer

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Citations

May 23, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·B J StantonB L Lasley
Feb 26, 2003·Phytotherapy Research : PTR·Saburo HidakaTakehiko Uesugi

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