PMID: 6979260May 1, 1982Paper

Effects of 2-n-butyl-methylenedioxyindene on skeletal muscle mechanics and energetics

The American Journal of Physiology
D M BurchfieldR G Rahwan

Abstract

Mechanical and energetic effects of 2-n-butyl-3-dimethylamino-5,6-methylenedioxyindene (2-butyl-MDI) were investigated in isolated frog semitendinosus muscles at 0 degrees C. Previous research on various tissues suggested that this compound functions as an intracellular Ca2+ antagonist. The effects of 2-butyl-MDI (2 X 10(-4) M) with respect to time were progressive and reversible with exposures of 30 min or less. A 30-min exposure to the agent significantly decreased twitch and tetanus force and energy liberation, increased the twitch-to-tetanus ratio, prolonged kinetics of force development, induced a stimulus frequency-dependent tetanic fatigue, and decreased contractile economy (measured as force per unit energy liberation). Energy associated with Ca2+ cycling, activation heat, was depressed by 31 +/- 4%. The significant reduction of activation heat production by 2-butyl-MDI suggests that the quantity of Ca2+ released by the sarcoplasmic reticulum upon stimulation is reduced. However, the complexity of the results summarized above suggests multiple sites and/or modes of action for the agent.

References

Jul 1, 1978·Physiological Reviews·N A Curtin, R C Woledge
May 1, 1979·Canadian Journal of Physiology and Pharmacology·R G RahwanD T Witiak
Feb 1, 1972·The Journal of Physiology·I C Smith
Jun 1, 1980·The Journal of General Physiology·J A Rall

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Citations

Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·T S Tracy, C D Black
Apr 1, 1989·Journal of Bioenergetics and Biomembranes·P PaladeG Hals
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M M BerensonD J Bjorkman
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R Bloomer
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R UtiliH J Zimmerman

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