Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis

Cancer Letters
H SatoY Hayashi

Abstract

Two metabolites of sodium o-phenylphenate (OPP-Na), 2-phenyl-1,4-benzoquinone (PBQ) and 2,5-dihydroxybiphenyl (5-OH), were examined for initiating, promoting or complete carcinogenic activity for skin carcinogenesis in female CD-1 mice. While PBQ treatment (1 mg per mouse, twice a week for 34 weeks) did cause sustained hyperplasia like 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment (2.5 micrograms, twice/week for 34 weeks), it showed weak, but not statistically significant, tumor promoting potential for skin tumor development initiated with 7,12-dimethylbenz[a]anthracene (DMBA, 10 micrograms x 10 in 5 weeks). On the other hand, 5-OH applied at a dose of 10 mg/mouse using a similar protocol did not exert any promoting influence, and neither of these chemicals administered continually for 40 weeks without prior DMBA initiation treatment induced any skin tumors. Furthermore, both chemicals applied 10 times in 5 weeks at higher doses (2 mg for PBQ and 20 mg for 5-OH) in association with subsequent TPA treatment did not initiate any skin tumor development. Thus, neither of the OPP-Na metabolites demonstrated any capacity to influence skin tumor development in any manner, despite the fact that OPP-Na itself was previously found...Continue Reading

References

Jan 1, 1984·Environmental Mutagenesis·T W Kensler, M A Trush
Nov 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Hiraga, T Fujii
Jun 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T NakaoK Hiraga
Jan 1, 1983·Chemico-biological Interactions·R H ReitzP G Watanabe

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Citations

Nov 1, 1992·Environmental Health Perspectives·Y Kurokawa, T Damstra
Dec 18, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shigehisa UchiyamaNaoki Kunugita
Dec 19, 2002·Critical Reviews in Toxicology·E M BomhardM Richter

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