Effects of 3'-azido-3'-deoxythymidine (AZT) on short-term cultured human peripheral blood lymphocytes

European Journal of Clinical Investigation
P TaurisF T Black

Abstract

Although an optimal dose-regimen has still not been established, the antiviral drug 3'-azido-3'-deoxythymidine is known to improve the clinical condition of patients suffering from acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related complex. The drug effect has mainly been assessed in terms of survival time and/or immunological parameters. One of the most prominent immunological features associated with immunodeficiency virus infection is a persistant hypergammaglobulinaemia due to in vivo polyclonal B-lymphocyte activation. In vitro this is reflected by a hyporesponsiveness of peripheral blood B-lymphocytes to mitogen and antigen induced activation. The present paper deals with the in vitro impact of 3'-azido-3'-deoxythymidine on the immunoglobulin secretion in short-term cultures of peripheral blood lymphocytes. Twenty-four human immunodeficiency virus antibody positive (seropositive) and 24 antibody negative (seronegative) individuals were studied. In addition, T- and B-cell proliferation and the distribution of cell surface markers were determined in 3'-azido-3'-deoxythymidine-supplemented cultures of peripheral blood lymphocytes from eight seronegative subjects. At concentrations similar to th...Continue Reading

References

Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P A FurmanH Mitsuya
Jun 1, 1986·Clinical Immunology and Immunopathology·I R KatzM K Hoffmann

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Citations

Jan 15, 1991·Biochemical Pharmacology·D R ShawJ P Sommadossi
Jun 20, 2000·Antimicrobial Agents and Chemotherapy·S FranckeL E Mathes
Jul 1, 1996·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·S SchubertU Ullmann
Jul 8, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·F O FatoyeG K Fatoye
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Sep 1, 1996·Antimicrobial Agents and Chemotherapy·L E MathesG Kociba

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