PMID: 2501188May 1, 1989Paper

Effects of 3-methylsulphonyl-4,5,3',4-tetrachlorobiphenyl and 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity

Fukuoka igaku zasshi = Hukuoka acta medica
J NagayamaT Hirohata

Abstract

First, we examined the effects of 3-methylsulphonyl-4,5,3',4',-tetrachlorobiphenyl (3-MSF-TCB, 1.5 ppm) and 7,8-benzoflavone (ANF, 1.4 ppm) on aryl hydrocarbon hydroxylase (AHH) activity in cultured human lymphoblastoid cells and we have obtained the following results: (1) 3-MSF-TCB preferentially inhibited the enzyme activity induced by 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and slightly stimulated the enzyme activity induced by 3-methylcholanthrene (MC). (2) ANF reduced well the AHH activities induced by all the three enzyme inducers and more strongly inhibited the PenCDF- or TCDD-induced enzyme activity (about 89%). (3) About 64 and 76% of basal (uninduced) AHH activity was lowered by 3-MSF-TCB and ANF, respectively. Second, we investigated the effect of 3-MSF-TCB (1.5-45 ppm) and ANF (1.4-42 ppm) on AHH activity of hepatic microsomes from the Ah nonresponsive (DDD) and responsive (C3H) strains of mice and we have got the following results: (1) 3-MSF-TCB and ANF enhanced or reduced the enzyme activity depending on both their concentrations and kinds of microsomes, namely, those prepared from untreated mice (control-microsomes) and mice treated with MC (MC-microsomes) or TCDD ...Continue Reading

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