Effects of 3,3'-Iminodipropionitrile on Hair Cell Numbers in Cristae of CBA/CaJ and C57BL/6J Mice

Journal of the Association for Research in Otolaryngology : JARO
Brent A WilkersonOlivia Bermingham-McDonogh

Abstract

This study examines absolute hair cell numbers in the cristae of C57BL/6J mice and CBA/CaJ mice from weaning to adulthood as well as the dose required for 3,3'-iminodiproprionitrile (IDPN)-injury of the cristae in C57BL/6J mice and CBA/CaJ mice, the two mouse strains most commonly used by inner ear researchers. In cristae of CBA/CaJ and C57BL/6J mice, no loss of hair cells was observed up to 24 weeks. In both strains, dose-dependent loss of hair cells was observed 7 days after IDPN treatment of 2-month-old mice (IC50 = 16.1 mmol/kg in C57BL/6J mice vs. 25.21 mmol/kg in CBA/CaJ mice). Four-month-old C57BL/6J mice exposed to IDPN developed dose-dependent vestibular dysfunction as indicated by increased activity and circling behavior in open field tests and by failure to swim 7 days after treatment. IDPN-hair cell injury in C57BL/6J mice and CBA/CaJ mice represents a fast and predictable experimental model for the study of vestibular degeneration and a platform for the testing of vestibular therapies.

References

Jan 1, 1991·Acta Oto-laryngologica·H S Li, E Borg
Jun 1, 1997·The Journal of the Acoustical Society of America·V P SpongrR J Salvi
Jan 23, 2002·Nihon Jibiinkoka Gakkai kaiho·A UnoT Kato
Apr 2, 2004·Nature·Jan SiemensUlrich Müller
Apr 2, 2004·Nature·Christian SöllnerUNKNOWN Tübingen 2000 Screen Consortium
Jul 9, 2004·Journal of Neurophysiology·Sapan S DesaiAnna Lysakowski
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zubair M AhmedThomas B Friedman
Dec 13, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carla Soler-MartínJordi Llorens
Mar 3, 2007·The European Journal of Neuroscience·Ronna HertzanoKaren B Avraham
May 20, 2008·Auris, Nasus, Larynx·Min YinYutaka Shibata
Oct 29, 2008·Archives of Internal Medicine·Hannelore K NeuhauserThomas Lempert
Jan 15, 2010·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·B GopinathP Mitchell
Jun 10, 2010·Genesis : the Journal of Genetics and Development·Hua YangLin Gan
Sep 10, 2010·Journal of Vestibular Research : Equilibrium & Orientation·Barbro MendelAnn Langius-Eklöf
Nov 6, 2010·Journal of the Association for Research in Otolaryngology : JARO·Bruce MockSherri M Jones
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent LinJennifer S Stone
May 31, 2012·The Laryngoscope·Harrison W Lin, Neil Bhattacharyya
Feb 27, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jae Yun JungYehoash Raphael
Aug 31, 2013·Journal of the Association for Research in Otolaryngology : JARO·Amber D Slowik, Olivia Bermingham-McDonogh
Nov 1, 2013·Reproductive Toxicology·Noriyuki TakahashiBunpei Ishizuka
Jan 20, 2015·JAMA Internal Medicine·Christine T CigolleCaroline S Blaum
Oct 16, 2015·Nature Communications·Joseph C BurnsMatthew W Kelley
Sep 23, 2016·MMWR. Morbidity and Mortality Weekly Report·Gwen BergenElizabeth R Burns
Oct 19, 2016·Journal of the Association for Research in Otolaryngology : JARO·Kevin K OhlemillerKenneth R Johnson
Jul 26, 2017·ELife·Ksenia GnedevaA J Hudspeth

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.