PMID: 6104700May 1, 1980

Effects of 3,4-dihydroxyphenylpyruvic acid and L-glutamic acid on some pharmacokinetic parameters of L-dopa in the rat

The Journal of Pharmacy and Pharmacology
I B Lindén

Abstract

In the rat, various oral doses of 3,4-dihydroxyphenylpyruvic acid (DHPPA) administered simultaneously with L-dopa were shown to elevate the serum L-dopa and cerebral dopamine concentrations dose-dependently. With increasing DHPPA: L-dopa ratio the L-dopa-sparing effect became greater. Although oral and intravenous doses of DHPPA showed that it was readily converted to L-dopa in the serum, only small amounts of dopamine (DA) were detected in the brain. The high 3-O-methyldopa concentrations, measured in the serum after DHPPA administration, might be responsible for the failure of the L-dopa formed to pass the blood-brain barrier. Concomitant administration of L-dopa and glutamic acid gave significantly higher L-dopa values in the serum and DA and homovanillic acid values in the brain than did the same dose of L-dopa alone. This indicates that the transamination of L-dopa can also be effected by coadministration of L-dopa and an amino group donor in vivo.

References

Nov 1, 1977·Journal of Pharmaceutical Sciences·B K Kim, R T Koda
May 1, 1969·The Journal of Pharmacy and Pharmacology·G BartholiniA Pletscher
May 1, 1971·European Journal of Clinical Investigation·L Rivera-CalimlimJ R Bianchine
Feb 1, 1964·Journal of Neurochemistry·F FONNUMO TANGEN

Citations

Sep 6, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nelida FernandezJuan J Garcia
Sep 1, 1982·Acta Pharmacologica Et Toxicologica·I B LindénH Vapaatalo
Nov 1, 1982·Acta Pharmacologica Et Toxicologica·I B Lindén, S Niemi

Related Concepts

3,4-dihydroxyphenylpyruvic acid, alpha-(14)C-labeled
Brain Chemistry
Intropin
Drug Interactions
Glutamic Acids
Homovanillic Acid
Levopa
Sembrina
Phenylpyruvic Acids

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