Effects of 4-aminopyridine on insulin secretion and plasma glucose levels in intact and adrenalectomized-chemically sympathectomized mice

European Journal of Pharmacology
B AhrénI Lundquist

Abstract

The effects of 4-aminopyridine (4-AP) on basal and glucose-induced insulin secretion and on plasma glucose concentrations were investigated in vivo in intact mice and in mice subjected to surgical adrenalectomy plus chemical sympathectomy induced by 6-hydroxydopamine. In normal intact mice, an i.v. injection of 4-AP, 26 micro mol/kg, induced an elevation of plasma glucose concentrations from 6.4 +/- 2 to 10.0 +/- 0.3 mmol/1 (P less than 0.001) seen after 30 min. Thereafter the plasma glucose concentration gradually returned to the normal level. Despite this marked elevation of plasma glucose levels, no change in plasma insulin concentrations was seen. In intact normal mice, the insulin secretion induced by a half-maximal dose of glucose was partially inhibited by 4-AP, 0.26 micro mol/kg. No further inhibition was observed after a larger dose, 26 micro mol/kg. In adrenalectomized-chemically sympathectomized mice, 4-AP, 26 micro mol/kg, did not affect plasma glucose concentrations or plasma levels of insulin. In these animals, 4-AP potentiated glucose-induced insulin secretion by approximately 65% at the two dose levels studied. This potentiation of glucose-induced insulin secretion was not affected by muscarinic receptor blockad...Continue Reading

References

Nov 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·H LundhI Rosén
Jan 1, 1978·Analytical Biochemistry·M L Bruss, A L Black
Sep 1, 1978·The Journal of Clinical Investigation·B J FrankelG M Grodsky
Oct 6, 1978·Cell and Tissue Research·I Lundquist, L E Ericson
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·P H Smith, D Porte
Jan 1, 1977·Journal of Neural Transmission·E S ViziF F Foldes
Jan 1, 1976·Biophysical Journal·J Z YehT Narahashi
Apr 1, 1981·Pflügers Archiv : European journal of physiology·B Ahrén, I Lundquist

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