PMID: 6407153Feb 1, 1983Paper

Effects of 4-dimethylaminophenol, Co2EDTA, or NaNO2 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning

Toxicology
R KlimmekN Weger

Abstract

The effects of the cyanide antidotes DMAP, Co2EDTA, and NaNO2 on cerebral blood flow (CBF) and cerebral blood gases were investigated in connection with acute poisoning of dogs by cyanide. The substances were injected intravenously. Local CBF as measured with thermocouples in the cingulum increased by 100-200% after a non-lethal dose of KCN (1 mg/kg) and by 50% after injection of NaNO2 (15 mg/kg), that oxidized some 20% of the total hemoglobin to ferrihemoglobin. Co2EDTA (10 mg/kg) induced a decrease in local CBF of 30% and in brain temperature of 0.5 degree C. The temperature diminished also after poisoning by KCN, but it rose by 0.15 degree C after the administration of NaNO2. Local CBF and sinus sagittalis blood flow increased by 60-160% for about 15 min, and the brain temperature decreased by 0.4-0.5 degree C when DMAP (3.25 mg/kg) or Co2EDTA (15 mg/kg) was injected 1 min after poisoning by cyanide (4 mg/kg), a dose that always caused respiratory arrest. Immediately after injection of DMAP the brain temperature rose transiently by 0.1-0.2 degree C. Co2EDTA did not exert such an effect. In the sinus sagittalis blood of artificially ventilated animals pCO2 decreased rapidly by 10-20 mmHg after poisoning and approached the ini...Continue Reading

References

Jan 1, 1974·Toxicology and Applied Pharmacology·G E Isom, J L Way
Jun 1, 1968·Canadian Journal of Biochemistry·G S Wiberg
Jan 1, 1981·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R KlimmekN Weger

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Citations

Aug 10, 2001·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·I A KhanK Jamil
Sep 1, 1985·Archives of Toxicology·R Klimmek, P Eyer
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T C MarrsA C Woodman
May 4, 2004·Blood Cells, Molecules & Diseases·André DejamMark T Gladwin
Jul 27, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ophir Lavon, Yedidia Bentur
Jan 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J E BrightS G Wood
May 23, 2007·Nitric Oxide : Biology and Chemistry·Joseph M RifkindAvraham Mayevsky

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