PMID: 8972549Dec 1, 1996Paper

Effects of 5-HT1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat

Psychopharmacology
K J Stanhope, C T Dourish

Abstract

In the present study, the effects of 5-HT1A receptor ligands with varying degrees of intrinsic activity at the 5-HT1A receptor were examined in the conditioned emotional response (CER) test and their effects compared to those of the benzodiazepine receptor agonists, diazepam and chlordiazepoxide. Diazepam (3.0 mg/kg) and chlordiazepoxide (3.0 mg/kg), and the 5-HT1A receptor partial agonists, ipsapirone (10.0 mg/kg) and gepirone (3.0 mg/kg), alleviated conditioned suppression of lever pressing. The 5-HT1A receptor partial agonist, buspirone (0.1-1.0 mg/kg), the 5-HT1A receptor agonist, 8-OH-DPAT (0.01-0.10 mg/kg), and the 5-HT1A receptor antagonist, WAY-100635 (0.03-3.0 mg/kg), had no effects on conditioned fear. Neither enhancing the level of food deprivation nor pretreatment with the amnesic agent scopolamine induced anxiolytic-like effects in the present CER test. The anxiolytic-like effects of ipsapirone in this test were completely reversed by WAY-100635. These results indicate that 5-HT1A agonist, but not antagonist actions, induce an anxiolytic effect in the CER test in rats.

Citations

Dec 9, 2003·European Journal of Pharmacology·Marilia BarrosCarlos Tomaz
Jul 29, 2000·European Journal of Pharmacology·J A BouwknechtB Olivier
Feb 26, 2003·European Journal of Pharmacology·Mark J Millan, Mauricette Brocco
Sep 22, 2001·Pharmacology, Biochemistry, and Behavior·H DemeulemeesterB Nuttin
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·James R MartinGuy A Higgins
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·D L MendozaH H Swanson
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·R BellP Mitchell
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Dec 16, 2004·Behavioral Neuroscience·C A J BlairGeoffrey Hall
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L K HeislerL H Tecott
Jan 19, 2016·Frontiers in Behavioral Neuroscience·Daniela R de OliveiraSuzete M Cerutti
Oct 13, 2009·European Journal of Pharmacology·Guy A HigginsMalik Slassi
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Aug 30, 2003·Biological Psychiatry·Zul MeraliHymie Anisman
Aug 21, 2014·Journal of Physical Therapy Science·Kyungjin Ha, Seungjun Choi
Apr 4, 2002·Journal of Neurophysiology·James E Monckton, David A McCormick
Apr 9, 2005·The Journal of Pharmacology and Experimental Therapeutics·M P G KorsgaardN R Mirza
Oct 26, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sukonthar NgampramuanEugene Nalivaiko
Oct 15, 2005·The Journal of Pharmacology and Experimental Therapeutics·Linda M Rorick-KehnDavid L McKinzie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.