Effects of 5-HT2 receptor antagonist on cycloheximide-induced amnesia in mice

Pharmacology, Biochemistry, and Behavior
T NabeshimaT Kameyama

Abstract

A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (+/-)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.

References

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Citations

Oct 10, 1989·European Journal of Pharmacology·T NabeshimaT Kameyama
Nov 19, 1991·European Journal of Pharmacology·T NabeshimaT Kameyama
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·A Meneses, E Hong
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·P A Palumbo, J C Winter
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·A Meneses, E Hong
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Meneses
Jan 1, 1994·Behavioral and Neural Biology·A Meneses, E Hong
Aug 1, 1997·Behavioural Brain Research·A Meneses, E Hong
Feb 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Meneses, E Hong
Dec 11, 1999·The American Journal of Chinese Medicine·Y H ChangC R Wu
Oct 3, 2002·Molecular and Cellular Neurosciences·Tatyana StrekalovaMelitta Schachner

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