PMID: 8444719Jan 1, 1993Paper

Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex

Journal of Applied Physiology
R A StoneP J Barnes

Abstract

In some species serotonin (5-HT) has been shown to act as a central modulator of the cough reflex. To investigate whether serotonergic mechanisms influence the control of the human cough reflex, we have induced cough responses before and during infusions of 5-HT; its precursor 5-hydroxytryptophan (5-HTP), which, in contrast to 5-HT, crosses the blood-brain barrier; and saline control. At the start of each study day, eight normal male volunteers were challenged with a single inhalation of a solution lacking chloride ions (0.15 M sodium bicarbonate) and a single breath of capsaicin during a sham infusion. After 3 h they received repeat cough challenges during experimental infusions of 5-HT, 5-HTP, or saline control, which were given randomly and single blind. Heart rate, respiratory rate, and blood pressure were measured before, during, and after each infusion. Both 5-HT and 5-HTP reduced cough responses to the chloride-deficient solution (P = 0.035 and P = 0.017, respectively) with respect to saline control, whereas neither infusion reduced responses to capsaicin. 5-HT caused a transient increase in heart rate that was not observed with a similar dose of 5-HTP or saline (P < 0.01). Respiratory rate and blood pressure were not af...Continue Reading

Citations

Jul 16, 1999·Pediatric Pulmonology·A B Chang
Jul 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hiam Abdala-ValenciaJoan M Cook-Mills
Jun 27, 2001·Acta Oto-laryngologica·R UddmanL Edvinsson
Jun 27, 2002·Expert Opinion on Investigational Drugs·K F Chung
Dec 1, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yang-Ling ChouBrendan J Canning
Nov 15, 2020·Lung·Peter V Dicpinigaitis, Brendan J Canning
Oct 18, 2001·Pulmonary Pharmacology & Therapeutics·P J Barnes

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