Effects of 5-Pyrimidinol Derivative SNK-41 on Cytokine Profile of Mice with Lewis Lung Carcinoma

Bulletin of Experimental Biology and Medicine
O S KuznetsovaL P Kovalenko

Abstract

We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumors on day 9 of tumor development. In mice receiving SNK-411 in doses of 25 and 50 mg/kg, IL-4 content significantly decreased (by 4.0 and 3.6 times) on days 2-8 of carcinoma development; IL-2 content decreased by 1.4 and 1.2 times and IL-6 content decreased by 2.7 and 1.6 times, respectively, in comparison with control mice with tumors. Injections of SNK-411 in the same doses on days 8-15 of carcinoma development led to a significant decrease in IL-4 levels (by 2.2 and 4.5 times, respectively, in comparison with control mice with tumors) and did not affect serum levels of other cytokines.

References

Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Aug 15, 2008·Cytokine·Giovanni GermanoAlberto Mantovani
Dec 17, 2009·Cellular & Molecular Immunology·Zhiguang LiZhihai Qin
Jul 18, 2012·Bulletin of Experimental Biology and Medicine·V S ShishkinaE M Tararak
Feb 21, 2014·Seminars in Immunology·Koji Taniguchi, Michael Karin

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Citations

Jul 12, 2020·Bulletin of Experimental Biology and Medicine·K V KorzhovaA D Durnev

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