PMID: 2501811Jan 1, 1989Paper

Effects of 5HT-1A agonists on locomotor and investigatory behaviors in rats differ from those of hallucinogens

Psychopharmacology
S M Mittman, M A Geyer

Abstract

Behavioral profiles composed of both locomotor activity and investigatory behavior were established for the 5HT-1A agonists 8OHDPAT, buspirone, gepirone, and ipsapirone using rats tested in a Behavioral Pattern Monitor. Typically these compounds dose-relatedly decreased horizontal locomotion and investigatory activity during the first half of the 1-h test session. Time-course studies revealed that the time interval between injection and placement of the animal in the testing chamber made no difference in the temporal distribution of locomotor activity following most 5HT-1A agonists. These results were compared and contrasted to the behavioral profiles previously established for hallucinogenic compounds such as LSD and DOM, the psychoactive properties of which have been suggested to be mediated by 5HT-2 binding sites. Examination of ipsapirone and 8OHDPAT in a familiar environment paradigm revealed that both drugs decreased behavioral responding independently of the animals' familiarity with the test environment, in contrast to the behaviorally suppressive effects of hallucinogenic 5HT-2 antagonists which disappear in a familiar environment. Additionally, d,l-propranolol was used as a 5HT-1 antagonist and was found to block the ...Continue Reading

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Citations

Jan 1, 1990·Psychopharmacology·L L WingM A Geyer
Jan 1, 1993·Psychopharmacology·R J BlanchardD C Blanchard
Aug 6, 1991·European Journal of Pharmacology·S AhleniusA Wijkström
Mar 31, 1992·European Journal of Pharmacology·K C CorleyM C Boadle-Biber
Sep 25, 1995·European Journal of Pharmacology·L Cervo, R Samanin
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·C DeansA Goudie
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·S K Yeghiayan, A E Kelley
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·R Bell, H Hobson
Jan 1, 1994·Pharmacology & Therapeutics·P ChopinM Briley
Jan 1, 1996·Behavioural Brain Research·M A Geyer
Jun 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L BjörkT Lewander
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·V HillegaartS Ahlenius
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Diana L Martinez-Price, Mark A Geyer
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·F BorsiniN Pitsikas
Dec 20, 1999·Behavioural Brain Research·J FrohlichD Pfaff
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C CannizzaroA Mineo
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Jul 22, 1999·Annals of the New York Academy of Sciences·K Scearce-LevieR Hen
Jun 22, 2010·Behavioural Brain Research·Leah GrossmanAllan V Kalueff
Apr 9, 2008·Behavioural Brain Research·B BertH Bönisch
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Jan 31, 2006·Journal of Ethnopharmacology·M E Gonzalez-TrujanoA Navarrete
Jan 25, 2011·Neuropharmacology·Adam L Halberstadt, Mark A Geyer
Jul 19, 2014·Behavioural Brain Research·Adam L Halberstadt
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M L Vianna, Pascal Carrive

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