PMID: 6403775Apr 1, 1983Paper

Effects of 6- and 7-hydroxy metabolites of 3 beta,17 beta-dihydroxy-5 alpha-androstane on gonadotrophin and prolactin secretion and on sex accessories weight of male rats

Journal of Steroid Biochemistry
F CelottiE Santaniello

Abstract

It has recently been shown that 3 beta,17 beta-dihydroxy-5 alpha-androstane (3 beta-diol), a known testosterone metabolite, may be further hydroxylated in position 6 and 7. Because of the possible involvement of 3 beta-diol in the control of gonadotrophin secretion, this work was aimed at investigating the effects of 3 beta,6 alpha,17 beta-trihydroxy-5 alpha-androstane (6 alpha-triol), 3 beta,7 alpha,17 beta-trihydroxy-5 alpha-androstane (7 alpha-triol), 3 beta,6 beta,17 beta-trihydroxy-5 alpha-androstane (6 beta-triol) and 3 beta,7 beta,17 beta-trihydroxy-5 alpha-androstane (7 beta-triol) on the secretion of LH, FSH and prolactin in long term castrated male rats. The four triols, 3 beta-diol and 3 alpha,17 beta-dihydroxy-5 alpha-androstane (3 alpha-diol), used for comparison, were given in a single subcutaneous dose of 2 mg/rat. Animals were killed 2, 5, 8 and 24 h after injection. None of the six steroids produces any significant effect on serum levels of FSH and prolactin at the 4 time intervals considered. On the contrary, LH levels are significantly reduced 2, 5 and 8 h after the injection of 7 beta-triol. This effect appears rapidly but is short lasting, since it disappears in the 24 h blood sample, 3 alpha-Diol also inhi...Continue Reading

References

Jul 1, 1979·Journal of Steroid Biochemistry·S Samperez, P Jouan
Nov 1, 1975·Journal of Steroid Biochemistry·E J Van DoornA F Clark
Feb 1, 1973·The Journal of Endocrinology·M ZanisiL Martini
Jan 1, 1970·Acta Endocrinologica. Supplementum·D Rodbard, J E Lewald
Jul 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderL E Reichert
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderS Ellis
Jul 5, 1966·Journal of the American Chemical Society·D H BartonM M Pechet

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Citations

Jul 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·R Morfin, G Courchay
Apr 12, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Robert Morfin
Aug 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·A C CotillonR Morfin
Jul 23, 1999·The Journal of Steroid Biochemistry and Molecular Biology·A C Cotillon, R Morfin

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