PMID: 9179179Jun 1, 1997Paper

Effects of 72 hours sleep deprivation on wound healing in the rat

Research in Nursing & Health
C A Landis, J D Whitney

Abstract

The purpose of this study was to examine effects of sleep deprivation on cellular and biochemical markers of wound healing. Expanded polytetrafluoroethylene tubing inserted in subcutaneous tissue created miniature wounds in the dorsal skin of 12 rats. Seven days later, 6 rats were deprived of sleep by the platform method for 72 hr; control rats remained on usual sleep/wake routines. Numbers of macrophages, granulocytes, fibroblasts, and extent of connective tissue present and total amounts of protein, DNA, and hydroxyproline in the implants were not different between sleep-deprived and control rats. There is no evidence from this study that sleep deprivation impairs cellular and biochemical indicators of tissue repair.

Citations

Jun 3, 2004·Nature Reviews. Immunology·Penelope A BryantNigel Curtis
Oct 30, 2004·The International Journal of Neuroscience·Kenan GümüştekinErhan Varoglu
Jun 10, 2011·Medical Hypotheses·F EgydioM L Andersen
Aug 5, 2016·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Barbara Pieper, Thomas N Templin
Feb 7, 2001·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·B S Schneider, J H Flaskerud
Aug 27, 2005·Journal of Sleep Research·L MostaghimiR M Benca
May 4, 2006·Journal of Wound Care·R Harper, L Anson
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aalim M WeljieAmita Sehgal
Dec 2, 2020·Current Biology : CB·Marina P SinnerHenrik Bringmann

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