Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment

The Journal of Endocrinology
Julie ChristoffelWolfgang Wuttke

Abstract

Phytoestrogens are increasingly consumed in artificially high doses as herbal preparations and nutritional supplements. The flavanone 8-prenylnaringenin (8PN) is a potent phytoestrogen, but its benefits and risks after long-term application are poorly identified. Therefore, we tested two doses of 8PN and 17beta-estradiol-3-benzoate (E2B) (effective doses: 6.8 and 68.4 mg/kg body weight (BW) of 8PN, and 0.17 and 0.7 mg/kg BW of 17beta-estradiol (E2)) and compared their effects on uterine weight, pituitary hormones (LH, FSH and prolactin) and the expression of estrogen-regulated genes and of estrogen receptor (ER)alpha and ERbeta in the hypothalamus, pituitary and uterus. Both doses of E2 and the high dose of 8PN suppressed serum LH and FSH, and stimulated serum prolactin levels, uterine weight, and progesterone receptor, insulin-like growth factor I and complement protein C3 mRNA transcripts. In the preoptic and the mediobasal areas of the hypothalamus, all treatments had negligible effects on ERalpha and ERbeta and gonadotropin-releasing hormone (GnRH) receptor gene expression, while ERbeta and GnRH receptor transcripts in the anterior pituitary were reduced under both E2 doses and the high 8PN dose. The mRNA concentrations of ...Continue Reading

Citations

Feb 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R ErkkolaA Heyerick
Mar 1, 2008·Journal of Ethnopharmacology·Paola Zanoli, Manuela Zavatti
Oct 2, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dominik RachońWolfgang Wuttke
Jul 11, 2012·Journal of Cellular Physiology·Lei-Guo MingCory J Xian
May 21, 2010·Molecular Nutrition & Food Research·Selin BolcaHerman Depypere
Sep 13, 2016·Journal of Menopausal Medicine·Fatemeh AbdiNasibeh Roozbeh
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Charinya KhamphukdeeAnake Kijjoa
Apr 25, 2019·Journal of Agricultural and Food Chemistry·Mark LevissonJules Beekwilder

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