Effects of a 3-day low-fat diet on metabolic control, insulin sensitivity, lipids and adipocyte hormones in Norwegian subjects with hypertriacylglycerolaemia and type 2 diabetes

Scandinavian Journal of Clinical and Laboratory Investigation
I L MostadV E Grill

Abstract

The metabolic and hormonal impact of rapid dietary changes in type 2 diabetes has not been clarified. The objective of this study was to test whether a short-term, low-fat diet affected metabolic control, insulin sensitivity, lipids and adipocyte hormones in patients with type 2 diabetes with hypertriacylglycerolaemia. Nineteen outpatient subjects (10 M, 9 F) with type 2 diabetes and triacylglycerols >2.2 mmol/L at screening were included in the study. Dietary intake was assessed by weighing during two periods of 3-day baseline diet followed by a 3-day low-fat dietary intervention. The two periods of baseline diet did not differ with respect to relevant variables during intervention. Subjects were advised to increase fibre-rich and low-fat foods and to decrease intake of visible fat in an isoenergetic manner. The percentage of energy from fat was reduced from 39 to 22 (p < 0.0001), median values. Daytime blood glucose did not change and fasting insulin and fasting glucose to insulin ratios were unaffected. Total cholesterol decreased from 6.3 to 6.2 mmol/L (p < 0.005), high-density lipoprotein cholesterol from 1.13 to 1.10 mmol/L (p < 0.048) and the ratio of n-6 to n-3 fatty acids in phospholipids from 2.5 to 1.9 (p < 0.003). C...Continue Reading

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Citations

May 7, 2013·Diabetes & Metabolism·P E WändellA C Carlsson
Aug 4, 2009·Nutrition·Daniela S SartorelliUNKNOWN Japanese-Brazilian Diabetes Study Group
Oct 5, 2011·Nutrition Reviews·Flávia M SilvaAna M Feoli
Jun 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoRoberto Gambino
Mar 4, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoMaurizio Cassader
Oct 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoGianfranco Pagano

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