Effects of a 5-HT(3) antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging

Alimentary Pharmacology & Therapeutics
Luca MarcianiRobin C Spiller

Abstract

5-HT(3) antagonists have been shown to be effective in relieving the symptoms of irritable bowel syndrome with diarrhoea (IBS-D). Using a recently validated magnetic resonance imaging (MRI) method, we have demonstrated reduced fasting small bowel water content (SBWC) in IBS-D associated with accelerated small bowel transit. We hypothesized that slowing of transit with ondansetron would lead to an increase in SBWC by inhibiting fasting motility. To assess the effects of ondansetron compared with placebo in healthy volunteers on SBWC and motility in two different groups of subjects, one studied using MRI and another using manometry. Healthy volunteers were given either a placebo or ondansetron on the day prior to and on the study day. Sixteen volunteers underwent baseline fasting and postprandial MRI scans for 270 min. In a second study, a separate group of n = 18 volunteers were intubated and overnight migrating motor complex (MMC) recorded. Baseline MRI scans were carried out after the tube was removed. Fasting SBWC was markedly increased by ondansetron (P < 0.0007). Ondansetron reduced the overall antroduodenal Motility Index (P < 0.04). The subjects who were intubated had significantly lower fasting SBWC (P < 0.0002) compared...Continue Reading

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Citations

May 5, 2009·The AAPS Journal·Steven C Sutton
Dec 23, 2015·Molecular Pharmaceutics·Arjang TalattofGordon L Amidon
Feb 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L Marciani
Jul 26, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L MarcianiR C Spiller
May 29, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Robin Spiller, Caroline Hoad
Jun 17, 2020·World Journal of Gastroenterology : WJG·Qi-Yun XiaoGui-Jun Fei
Mar 9, 2021·Frontiers in Pharmacology·Esther ColomierChloé Melchior
Nov 14, 2019·Molecular Pharmaceutics·Maiara Camotti MontanhaPaulo Paixão
Aug 3, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Youyou LuLanwei Zhang

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