Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Shaun B SabicoPhilip G McTernan

Abstract

The aim of this trial was to characterize the beneficial effects of probiotics on decreasing endotoxin levels and other cardiometabolic parameters in Arab patients with type 2 diabetes mellitus (T2DM). Saudi adults with naïve T2DM (n = 30; 12 males and 18 females) were randomly allocated to receive twice daily placebo or 2.5 × 109 cfu/g of Ecologic®Barrier (multi-strain probiotics; n = 31; 14 males and 17 females) in a double-blind manner over a 6 month period, respectively. Anthropometrics were measured and fasting blood samples were collected to analyze endotoxin, glycemic parameters [glucose, insulin, c-peptide and homeostasis model assessment for insulin resistance (HOMA-IR)], lipids [triglycerides, total cholesterol, low and high-density lipoprotein (LDL and HDL, respectively) cholesterol and total/HDL-cholesterol ratio], inflammatory markers [tumor-necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP)] and adipocytokines [leptin, adiponectin and resistin] at baseline and after 3 and 6 months of intervention. Multi-strain probiotics supplementation for 6 months caused a significant decrease in circulating levels of endotoxin by almost 70% over 6 months, as well as glucose (38%), insulin (38%), HO...Continue Reading

Citations

Feb 23, 2020·Herz·Hendrik BartolomaeusNicola Wilck
Sep 18, 2020·The Journal of International Medical Research·Yayun WangYibing Lu
Jan 18, 2020·BioMed Research International·Periyanaina KesikaChaiyavat Chaiyasut
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Jun 19, 2021·Seminars in Nephrology·Wei Ling LauNosratola D Vaziri
Aug 1, 2021·Clinical Nutrition ESPEN·Kontham Kulangara VarshaKesavan Madhavan Nampoothiri
Aug 18, 2021·Metabolic Syndrome and Related Disorders·Diana Rodríguez-VeraRodolfo Pinto-Almazán
Aug 18, 2021·Food Research International·Chao TangYingjian Lu
Sep 19, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qin Huang, Jian Xia
Dec 18, 2021·Clinical Science·Nikita LadPhilip G McTernan

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