Effects of a 6-month self-rehabilitation programme in addition to botulinum toxin injections and conventional physiotherapy on limitations of patients with spastic hemiparesis following stroke (ADJU-TOX): protocol study for a randomised controlled, investigator blinded study

BMJ Open
Celine BonnyaudADJU-TOX Study Group

Abstract

Home-based self-rehabilitation programmes combined with botulinum toxin injections (BTIs) appear to be a relevant approach to increase the recommended intensive rehabilitation of patients with spasticity following a stroke. The literature highlights a lack of evidence of beneficial effects of this adjuvant therapy to reduce limitations of patients with stroke. The aim of this study is to assess the effects of a 6-month self-rehabilitation programme in adjunction to BTI, in comparison with BTI alone, to reduce limitations of patients with spasticity following a stroke. 220 chronic patients will participate to this multicentre, prospective, randomised, controlled, assessor blinded study. All patients will benefit from two successive BTI (3 months apart), and patients randomised in the self-rehabilitation group will perform in adjunction 6 months of self-rehabilitation at home. All patients continue their conventional physiotherapy. The main outcome is the primary treatment goal (PTG), which will be determined jointly by the patient and the medical doctor using Goal Attainment Scaling. Impairments and functions, quality of life, mood and fatigue will be assessed. Botulinum toxin will be injected into the relevant muscles according...Continue Reading

References

Dec 1, 1991·American Journal of Physical Medicine & Rehabilitation·D C KerriganJ Perry
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·J PerryS J Mulroy
Aug 18, 2000·Journal of Pain and Symptom Management·J WisselW Poewe
Sep 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·D RichardsonA Thompson
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Graeme J HankeyCraig S Anderson
Dec 1, 1951·Brain : a Journal of Neurology·T E TWITCHELL
Aug 6, 2004·Clinical Rehabilitation·UNKNOWN Glasgow Augmented Physiotherapy Study (GAPS) group
Nov 24, 2004·Neurology·M F GordonUNKNOWN BOTOX Poststroke Spasticity Study Group
May 7, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F ManciniC Pacchetti
Apr 6, 2006·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Stephen Ashford, Lynne Turner-Stokes
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Arlene SchmidSamuel S Wu
Sep 19, 2007·Neurorehabilitation and Neural Repair·Gert KwakkelHermano I Krebs
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Margaret Kelly-HayesPhilip A Wolf
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Boudewijn J KollenGert Kwakkel
Feb 7, 2009·Journal of Rehabilitation Medicine·Jörg WisselNiko Tieranta
May 23, 2009·Stroke; a Journal of Cerebral Circulation·Lotte WeversGert Kwakkel
Jul 18, 2009·Lancet Neurology·Peter LanghorneAlex Pollock
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G SheeanUNKNOWN Cerebral Palsy Institute
Sep 10, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Francesco FerrarelloMauro Di Bari
Mar 3, 2012·Pharmaceutical Statistics·Steven A Julious, Nikki E McIntyre
May 12, 2012·BMJ : British Medical Journal·Ingrid G L van de PortGert Kwakkel
Dec 25, 2012·Archives of Physical Medicine and Rehabilitation·Norine FoleyRobert Teasell
Jun 7, 2013·The Cochrane Database of Systematic Reviews·Marina DemetriosShane McSweeney
Nov 2, 2013·Stroke; a Journal of Cerebral Circulation·Cathy M StinearWinston D Byblow
Dec 1, 1968·Community Mental Health Journal·T J Kiresuk, R E Sherman
Jun 12, 2014·American Journal of Physical Medicine & Rehabilitation·Jean SlawinskiRaphaël Zory
Jul 31, 2014·Journal of Rehabilitation Medicine·Marina DemetriosFary Khan

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Jul 1, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Fang Yuan LuoMagali Robert
Oct 29, 2020·Journal of Medical Systems·Enjie GhorbelLeire Ortiz Fernandez

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