PMID: 6166835Jan 1, 1981Paper

Effects of a bacteriocin from Mycobacterium smegmatis on BALB/3T3 and simian virus 40-transformed BALB/c mouse cells

Microbiology and Immunology
H Saito, T Watanabe

Abstract

The effects of a bacteriocin from Mycobacterium smegmatis ATCC 14468 on simian virus 40-transformed BALB/c mouse cells (mKS-A TU-7 cells) and nontransformed BALB/3T3 cells originating from the BALB/c mouse strain were studied. The percentage of nigrosin-unstained (viable) cells in the bacteriocin-treated mKS-A TU-7 cells decreased time-dependently with an increase in the bacteriocin activity. There was a time-dependent decrease in the bacteriocin activity after treatment with the cell membrane preparation from mKS-A TU-7 cells. There was no apparent effect of the bacteriocin on the viability of nontransformed BALB/3T3 cells. Wheat germ agglutinin blocked the toxic effect of bacteriocin on mKS-A TU-7 cells. These results indicate that the higher sensitivity and binding capacity of the tumor cells to the bacteriocin is probably due to the presence of a large amount of N-acetyl-glucosamine or closely related sugar residues with a high affinity for bacteriocin, as compared with normal cells. The bacteriocin produced morphological alterations and inhibition of synthesis of ribonucleic acid, deoxyribonucleic acid and protein in the transformed but not in the nontransformed cells.

References

Mar 20, 1978·Biochimica Et Biophysica Acta·A Weerkamp, G D Vogels
Feb 1, 1978·Journal of Biochemistry·M Iijima
Apr 1, 1979·Antimicrobial Agents and Chemotherapy·H SaitoH Tomioka
Feb 1, 1976·Journal of Biochemistry·A HiroseK Imahori
Oct 1, 1971·Journal of Bacteriology·S F Sabet, C A Schnaitman
Feb 7, 1973·Nature: New Biology·P J Greenaway, D LeVine
Feb 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·M M Burger, A R Goldberg

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Citations

Oct 11, 2008·American Journal of Clinical Oncology·Gilbert CornutDenis Soulières
Dec 1, 2015·Frontiers in Pharmacology·Sumanpreet Kaur, Sukhraj Kaur

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