PMID: 6104743Apr 15, 1980Paper

Effects of a beta 1-selective adrenergic agonist in normal human volunteers

Klinische Wochenschrift
K A MeurerA Helber

Abstract

In healthy volunteers, the effects of prenalterol, a new beta 1-adrenoceptor agonist, on renal hemodynamics, excretory function, plasma-renin-activity, plasma cAMP concentration, and plasma and urinary norepinephrine were studied. Besides an increase in blood pressure, which was adjusted to about 20 mmHg above the resting values, and an increase of heart rate, prenalterol induced only transient decreases of urinary volume and free water clearance and in increase of sodium excretion. The other parameters measured did not change. Thus prenalterol mainly exerts positive inotropic and chronotropic effects and does not affect renal circulation.

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Citations

Jan 1, 1982·Pharmacology & Therapeutics·D B EvansH R Kaplan
Jan 10, 1985·The New England Journal of Medicine·L VanheesA Amery
Jun 1, 1982·Journal of Clinical and Hospital Pharmacy·M J KendallS Westerling
Dec 1, 1982·Acta Anaesthesiologica Scandinavica·P O Järnberg, L Westman
Jan 1, 1986·Acta Anaesthesiologica Scandinavica·L Westman, P O Järnberg
Jan 1, 1989·Journal of Toxicology and Environmental Health·P V Prasada RaoM K Bhatnagar
Nov 1, 1983·British Journal of Clinical Pharmacology·J StaessenA Amery
Apr 1, 1988·Journal of Endocrinological Investigation·C TantucciV Grassi
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·N Lustenberger

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