Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

Atherosclerosis
A MullanN Sattar

Abstract

To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical co-morbidity in a randomized placebo controlled pilot study. Randomly assigned active 250 ml beverages containing 361 mg of (poly)phenols and 120 mg of vitamin C or placebo (no polyphenol/vitamin C) were taken twice daily for 4 weeks. Both beverages contained 40 kcals/250 ml. The primary end-points were pulse wave velocity (PWV) and cutaneous microvascular responses to sodium nitroprusside (SNP) and acetyl choline (ACh) laser doppler iontophoresis. A range of established and novel plasma markers were also measured. Twenty subjects received active beverage and 19 placebo; all completed the study. There was no difference in cutaneous vascular response to either SNP or ACh with mean group differences (logΔ area under perfusion curve) of 0.30 (-0.65, 1.26) and 0.35 (-0.11, 0.81) respectively. Nor was there evidence of a change in log PWV with a mean group difference of 0.029 m/s (-0.042, 0.10). No significant differences were seen in plasma leptin, apolipoproteins, cystatin C...Continue Reading

References

Jun 20, 2001·Annals of Internal Medicine·K J JoshipuraW C Willett
Dec 18, 2001·Journal of Cardiovascular Pharmacology·Jane Elizabeth RamsayNaveed Sattar
Mar 19, 2005·Journal of Hypertension·Annette P van den ElzenMichiel L Bots
Jun 1, 2005·American Journal of Hypertension·Charalambos VlachopoulosChristodoulos Stefanadis
Aug 1, 2006·Journal of Hypertension·Naomi D L Fisher, Norman K Hollenberg
Nov 7, 2007·Circulation·Andreas J FlammerRoberto Corti
Jan 14, 2009·The British Journal of Nutrition·Junko NaguraUNKNOWN JACC Study Group
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chisa MatsumotoAkira Yamashina
Jun 4, 2010·Molecular Nutrition & Food Research·Gina BorgesAlan Crozier
Jan 20, 2011·European Heart Journal·Francesca L CroweUNKNOWN European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart Study Collaborators
Mar 17, 2012·Lancet·UNKNOWN Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) ConsortiumJuan Pablo Casas
May 9, 2012·Redox Report : Communications in Free Radical Research·Mariela Guevara-GarcíaJulio César García-Rodríguez
Feb 21, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A Tresserra-RimbauUNKNOWN PREDIMED Study Investigators

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Citations

Oct 18, 2016·Nutrition·Geir Bjørklund, Salvatore Chirumbolo
Aug 8, 2020·Molecular Nutrition & Food Research·Nikolaj Bech PoulsenPer Bendix Jeppesen
Jul 12, 2017·Journal of Nutrition and Metabolism·Lotte SmoldersRonald P Mensink
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aline Boveto SantamarinaLuciana Pellegrini Pisani
May 14, 2021·European Journal of Pharmacology·Moanna VillaluzAndrew MacKenzie
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Denisa MarginăAristidis Michael Tsatsakis

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