Effects of a bisphosphonate (1-hydroxy ethylidene-1,1 bisphosphonic acid) on osteoclast number during prolonged bed rest in healthy humans

Metabolism: Clinical and Experimental
D ChappardG Riffat

Abstract

Acute osteoporosis is known to occur after immobilization in spinal cord injured patients and is related to an early increase in osteoclastic bone resorption. Whether osteoporosis develops in healthy immobilized human patients is still a matter of controversy. Furthermore, acute osteoporosis was thought to be a good model to study the effects of weightlessness on the human skeleton and to adapt preventive procedures. A bed rest experiment was developed in the USSR on 15 healthy human volunteers to determine the precise effects on bone structure and cell activities. A preventive protocol, including an anti-osteoclastic drug (1-hydroxyethylidene-1,1 bisphosphonic acid; K salt) was investigated. Two transiliac bone biopsies were performed on the 15 individuals before and at the end of the 120-day bed rest period. Undecalcified bone biopsies were studied with automatic and semi-automatic image analyzers specially devoted to bone histomorphometry. Trabecular bone volume, osteoid amount, and eroded surfaces were measured. Osteoclast number was measured after histochemical identification of tartrate-resistant acid phosphatase. After the bed rest period, an insignificant bone loss was observed in healthy humans while osteoclast number ...Continue Reading

Citations

Jul 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D ChappardG Riffat
Jul 1, 1996·Clinical Orthopaedics and Related Research·K WallaceF S Kaplan
Sep 1, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Robert P HeaneyIan P Barton
Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y YoshidaT Nakamura
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Kenneth E S PooleElizabeth A Warburton
Jul 6, 2014·Annual Review of Nutrition·S M SmithS R Zwart
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O L BijvoetS E Papapoulos
Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D D BikleB P Halloran
Dec 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A I GrigorievL B Buravkova
Jan 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D ChappardC Picot
Oct 23, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E ZerwekhC Y Pak
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M NishikawaN Nagata
Jun 16, 2011·Clinical Physiology and Functional Imaging·Tomas CervinkaHarri Sievänen
Jul 1, 1992·The Journal of the American Paraplegia Society·A N Elias, G Gwinup
Dec 28, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chao Yang LiMitchell B Schaffler
Sep 1, 1992·Calcified Tissue International·S PalleC Alexandre
Nov 1, 1994·Calcified Tissue International·S SairanenM J Välimäki

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