Effects of a blended Chinese medicine, xiao-chai-hu-tang, on Lewis lung carcinoma growth and inhibition of lung metastasis, with special reference to macrophage activation

Japanese Journal of Pharmacology
H Ito, K Shimura

Abstract

The antitumor effects of Xiao-Chai-Hu-Tang (Shosaiko-To: SHX) with or without 5-fluorouracil (5-FU) or cyclophosphamide (CY) were examined in an experimental system of lung metastasis induced by Lewis lung carcinoma in C57BL/6crSlc mice. Lewis lung carcinoma cells were implanted into the footpads of the mice. Ten days later, the implanted tumors were surgically removed. The effects of SHX were evaluated by the number of lung surface nodules present 14 days after removal of the implanted tumor. The administration of SHX, p.o. (300 mg/kg X 2/day X 10) caused the antimetastatic effect. Therapy with SHX plus 5-FU or CY significantly inhibited the development of lung metastases. The number of peritoneal macrophages and the degree of the binding of C3 cleavage products (C3b) to macrophages were enhanced in the mice treated with SHX. Lung metastases were inhibited by the i.v. administration of peritoneal macrophages activated with SHX, p.o. These findings raise the possibility that SHX may have clinical value in the prevention of cancer metastasis.

Citations

May 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S AmagayaK Terasawa
Feb 1, 1996·Japanese Journal of Cancer Research : Gann·Y MatsuzakiK Okita
Apr 17, 2007·The American Journal of Chinese Medicine·Jung-San ChangChun-Ching Lin
Apr 12, 2000·Journal of Gastroenterology and Hepatology·I Shimizu
Jul 23, 2002·Biological & Pharmaceutical Bulletin·Takamasa OhnoYukio Ogihara
Jun 21, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jun-Kyoung LeeHyeun Kyoo Shin

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