Effects of a carbohydrate-restricted diet on hepatic lipid content in adolescents with non-alcoholic fatty liver disease: A pilot, randomized trial

Pediatric Obesity
Amy GossBarbara Gower

Abstract

Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common form of liver disease among adolescents in industrialized countries. While lifestyle intervention remains the hallmark treatment for NAFLD, the most effective dietary strategy to reverse NAFLD in children is unknown. The objective of this study was to determine the effects of a moderately CHO-restricted diet (CRD) vs fat-restricted diet (FRD) in adolescents with NAFLD on reduction in liver fat and insulin resistance. Thirty-two children/adolescents (age 9-17) with obesity and NAFLD were randomized to a CRD (<25:25:>50% energy from CHO:protein:fat) or FRD (55:25:20) for 8 weeks. Caloric intakes were calculated to be weight maintaining. Change in hepatic lipid content was measured via magnetic resonance imaging, body composition via dual energy X ray absorptiometry and insulin resistance via a fasting blood sample. Change in hepatic lipid did not differ with diet, but declined significantly (-6.0 ± 4.7%, P < .001 only within the CRD group. We found significantly greater decreases in insulin resistance (HOMA-IR, <.05), abdominal fat mass (P < .01) and body fat mass (P < .01) in response to the CRD vs FRD. These findings suggest that consumption of a moderatel...Continue Reading

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Citations

Sep 9, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Kim L AlmanHiba Jebeile
Dec 12, 2020·Pediatric Obesity·Johanna K DiStefano, Gabriel Q Shaibi
Dec 23, 2020·Nutrients·Marcela Parra-VargasJosep C Jimenez-Chillaron
Apr 27, 2021·JHEP Reports : Innovation in Hepatology·Magnus HolmerPer Stål
Apr 20, 2021·Clinical Liver Disease·Taisa Kohut, Jennifer Panganiban
May 7, 2021·Pediatric Obesity·Johanna K HoareNatalie B Lister
Apr 20, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Renata RisiMikiko Watanabe
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Jun 29, 2021·Nutrition Research Reviews·Yuqi GaoZhao Wang
Jul 31, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Georg SemmlerMichael Trauner

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