PMID: 6133444May 1, 1983Paper

Effects of a cardioselective beta 1 partial agonist (corwin) on left ventricular function and myocardial metabolism in patients with previous myocardial infarction

The American Journal of Cardiology
M F RousseauM F Vincent

Abstract

Corwin is a new selective beta 1 partial agonist, able to stabilize the beta 1 adrenoceptors at approximately 43% of their maximal activity. The aim of the study was to determine the effects of this agent in patients with coronary artery disease (CAD) and previous myocardial infarction (MI). In a first group of 14 patients, corwin increased significantly the peak (+)dP/dt (+35%; p less than 0.005), the global ejection fraction, and the ejection fraction of abnormally contracting segments (from 20 +/- 18 to 26 +/- 19%; p less than 0.02). Corwin also induced significant decreases in mean systolic (-8%; p less than 0.05) and mean diastolic (-38%; p less than 0.001) wall stress and accelerated the relaxation rate. In a second group of 11 patients, a metabolic study indicated that neither myocardial oxygen consumption (15 +/- 7 versus 15 +/- 7 ml/min; difference not significant) nor lactate extraction was modified by the drug. In this group, increases in peak (+)dP/dt, acceleration in ventricular relaxation (-8 ms in time constant of isovolumic pressure decrease; p less than 0.01), and decreases in left ventricular end-diastolic pressure also were noted after administration of corwin, both under basal conditions and during a cold pr...Continue Reading

References

Nov 1, 1982·The American Journal of Cardiology·M F RousseauL A Brasseur

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Citations

Sep 1, 1990·Clinical Cardiology·L ThierfelderH J Just
Jan 1, 1986·European Journal of Clinical Pharmacology·R J BowesA Harley
Feb 1, 1993·Cardiovascular Drugs and Therapy·H E BøtkerE V Sørensen
Jun 24, 1986·European Journal of Pharmacology·E Vigholt Sørensen, F Nielsen-Kudsk
Mar 30, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bao Ting Zhu
Jun 1, 1984·Journal of the American College of Cardiology·E Braunwald, W S Colucci
Dec 1, 1989·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Mar 1, 1990·Postgraduate Medical Journal·M J Kendall, R C Horton
Apr 1, 1990·Cardiovascular Drugs and Therapy·M de MarneffeM Englert
Jan 1, 1986·European Journal of Clinical Pharmacology·L BarriosH de Geest
Feb 1, 1984·The American Journal of Cardiology·J M DetryL A Brasseur
May 1, 1989·British Journal of Clinical Pharmacology·D B Barnett
Jan 1, 1989·British Journal of Clinical Pharmacology·H M Snow
Jan 1, 1989·British Journal of Clinical Pharmacology·M F RousseauA A Charlier
Feb 1, 1989·Journal of Clinical Pharmacy and Therapeutics·M K Davies
Oct 25, 2006·Expert Opinion on Pharmacotherapy·Masao Endoh, Masatsugu Hori
Nov 1, 1986·British Journal of Clinical Pharmacology·J W LammersC L van Herwaarden
May 6, 1991·The American Journal of Cardiology·S J VirkM K Davies
Jan 1, 1989·British Journal of Clinical Pharmacology·D G Waller
Oct 1, 1984·British Journal of Clinical Pharmacology·C G Löfdahl, N Svedmyr

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